gene

RPA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

10Outgoing

5Incoming

0Experiments

0Debates

Summary

RPA1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, inhibits, interacts with. Associated with Lymphoma, Ms. Connected to 11 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RPA1
Full Name	Replication Protein A1
Chromosome	17p13.2
Function	RPA1 (Replication Protein A1) is the largest subunit of the heterotrimeric RPA complex, which is essential for DNA replication, repair, and recombination.
Primary Expression	all proliferating cells and in neurons
Molecular Weight	70 kDa
Amino Acids	639 aa
UniProt ID	P27694
NCBI Gene ID	9137
Ensembl ID	ENSG00000132383
OMIM	179835
GeneCards	RPA1
Human Protein Atlas	RPA1
Associated Diseases	neurodegeneration
Interactions	DNA
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RPA1 — AlphaFold P27694 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RPA1["RPA1"]
    Lymphoma{"Lymphoma"}
    RPA1 -->|"inhibits"| Lymphoma
    Ms{"Ms"}
    RPA1 -->|"regulates"| Ms
    DNA["DNA"]
    RPA1 -->|"inhibits"| DNA
    DICER1["DICER1"]
    RPA1 -->|"regulates"| DICER1
    MICRORNAS["MICRORNAS"]
    RPA1 -->|"regulates"| MICRORNAS
    AND["AND"]
    RPA1 -->|"inhibits"| AND
    B_Cell["B Cell"]
    RPA1 -->|"expressed in"| B_Cell
    neurodegeneration["neurodegeneration"]
    RPA1 -->|"implicated in"| neurodegeneration
    SOX2["SOX2"]
    SOX2 -->|"interacts with"| RPA1
    DICER1 -->|"regulates"| RPA1
    MICRORNAS -->|"regulates"| RPA1
    DNA -->|"inhibits"| RPA1
    style RPA1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
Lymphoma	inhibits	disease	0.65
Ms	regulates	disease	0.65
MICRORNAS	regulates	gene	0.60
MICRORNAS	expressed_in	gene	0.60
DICER1	regulates	gene	0.60
DNA	inhibits	gene	0.60
B Cell	regulates	cell_type	0.60
B Cell	expressed_in	cell_type	0.55
DNA DAMAGE	inhibits	concept	0.50
Microrna	inhibits	pathway	0.50

Incoming (5)

Source	Relation	Type	Str
genes-rpa1	linked_to	wiki	1.00
MICRORNAS	regulates	gene	0.60
DNA	inhibits	gene	0.60
DICER1	regulates	gene	0.60
DICER1	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RPA1 in their description or question text

No additional research found