gene

ano1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ano1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

8Outgoing

6Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ANO1
Aliases	Anoctamin 1 (TMEM16A
Chromosome	11q13
Protein Family	Anoctamin/TMEM16
Protein Type	Channel
Function	This channel is distinct from voltage-gated chloride channels (CLCNs) and represents a major pathway for calcium-dependent chloride conductance in epithelial and neuronal cells[@hartmann2022].
Primary Expression	various tissues, including the gastrointestinal tract, respiratory epithelium, and sensory neurons
GeneCards	ANO1
Human Protein Atlas	ANO1
Olfactory bulb	involved in olfactory signal processing
Cortical neurons	contributes to neuronal excitability
Sensory neurons	particularly in dorsal root ganglion (DRG) neurons
Substantia nigra	region affected in Parkinson's disease[@patteson2021]
Associated Diseases	Neurodegeneration, Alzheimer's disease pathogenesis through several mechanisms, Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ANO1 (Anoctamin 1 (TMEM16A))

gene · 641 words

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Pathway Diagram

flowchart TD
    N0["ANO1"]
    N1["Als"]
    N0 -->|"activates"| N1
    N2["Ms"]
    N0 -->|"activates"| N2
    N3["Akt"]
    N0 -->|"activates"| N3
    N4["Cholesterol"]
    N0 -->|"activates"| N4
    N5["Pi3K"]
    N0 -->|"activates"| N5
    N6["CTNNB1"]
    N6 -->|"activates"| N0
    N7["PI3K"]
    N7 -->|"activates"| N0
    N8["AKT"]
    N8 -->|"activates"| N0
    N9["EGFR"]
    N9 -->|"activates"| N0
    N10["neurodegeneration"]
    N0 -->|"implicated in"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 pathway
    class N4 pathway
    class N5 pathway
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 gene

Outgoing (8)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ANO1	data_in	dataset_row	0.00
Als	activates	disease	0.65
Ms	activates	disease	0.65
Akt	activates	pathway	0.60
Cholesterol	activates	pathway	0.60
Pi3K	activates	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
PI3K	activates	gene	0.60

Incoming (6)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ANO1	data_in	dataset_row	0.00
genes-ano1	linked_to	wiki	1.00
CTNNB1	activates	gene	0.60
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
EGFR	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ano1 in their description or question text

No additional research found