protein

ESCRT-III

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ESCRT-III: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

1Hypotheses

1Analyses

11Outgoing

20Incoming

0Experiments

1Debates

No summary available yet.

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🔬 Protein Info

Gene Symbol	ESCRT
Pathways	Autophagy
GeneCards	ESCRT
Human Protein Atlas	ESCRT
Associated Diseases	SNCA, CHMP2B, CHMP4B, CHMP6
Interactions	ALPHA-SYNUCLEIN AGGREGATES, CHMP2A, CHMP2B, CHMP3, CHMP4B, CHMP6
KG Connections	31 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ESCRT_III["ESCRT-III"] -->|"involved in"| Endolysosome_Membrane_Repair["Endolysosome Membrane Repair"]
    style Endolysosome_Membrane_Repair fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ESCRT_III["ESCRT-III"] -.->|"inhibits"| __Synuclein["alpha-Synuclein"]
    style __Synuclein fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ALPHA_SYNUCLEIN_AGGREGATES["ALPHA-SYNUCLEIN AGGREGATES"] -.->|"inhibits"| ESCRT_III["ESCRT-III"]
    style ALPHA_SYNUCLEIN_AGGREGATES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    __Synuclein_Aggregates["alpha-Synuclein Aggregates"] -.->|"inhibits"| ESCRT_III["ESCRT-III"]
    style __Synuclein_Aggregates fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    SNCA["SNCA"] -->|"interacts"| ESCRT_III["ESCRT-III"]
    style SNCA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Collateral_Degradation["Collateral Degradation"] -->|"degrades"| ESCRT_III["ESCRT-III"]
    style Collateral_Degradation fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    MAPT["MAPT"] -->|"disrupts"| ESCRT_III["ESCRT-III"]
    style MAPT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style ESCRT_III fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (11)

Target	Relation	Type	Str
Autophagy	involved_in	pathway	0.90
Endolysosome Membrane Repair	involved_in	process	0.85
Autophagosome-Lysosome Fusion	regulates	process	0.85
α-Synuclein	inhibits	protein	0.80
lysosomal membrane repair	modulates	process	0.70
VPS4	interacts_with	gene	0.55
VPS4A	interacts_with	gene	0.55
tauopathy	regulates	disease	0.55
DAM microglia	expressed_in	cell_type	0.55
neurodegeneration	activates	disease	0.55
neurodegeneration	protects_against	disease	0.55

Incoming (20)

Source	Relation	Type	Str
ALPHA-SYNUCLEIN AGGREGATES	inhibits	protein	0.98
α-Synuclein Aggregates	inhibits	protein	0.95
α-Synuclein Aggregates	interacts_with	protein	0.90
SNCA	interacts_with	protein	0.90
SNCA	associated_with	protein	0.90
Collateral Degradation	degrades	mechanism	0.90
ALPHA-SYNUCLEIN AGGREGATES	degrades	protein	0.90
α-Synuclein Aggregates	binds	protein	0.85
CHMP2B	interacts_with	protein	0.85
SNCA	inhibits	gene	0.80
CHMP4B	associated_with	protein	0.60
CHMP6	associated_with	gene	0.55
CHMP2B	activates	gene	0.55
CHMP2B	associated_with	gene	0.55
CHMP2B	regulates	gene	0.55
CHMP2A	interacts_with	gene	0.55
CHMP3	interacts_with	gene	0.55
CHMP4B	interacts_with	gene	0.55
CHMP6	interacts_with	gene	0.55
CHMP4B	causes	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Blocking Tau Packaging into Small Extracellular Vesicles via	0.610	neuroscience	Trans-synaptic tau spreading and propaga

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does controlled lysosomal membrane permeabilization induce autophagy without

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.690

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study shows trehalose causes lysosomal membrane permeabilization (LMP) that

closed · Rounds: 4 · Score: 0.61 · 2026-04-21

Related Research

Hypotheses and analyses mentioning ESCRT-III in their description or question text

No additional research found