Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about autophagy initiation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| VPS34-BECLIN-1 COMPLEX | regulates | protein | 0.95 |
| ULK1 | regulates | protein | 0.95 |
| ULK1 Complex | involved_in | protein | 0.90 |
| MTOR | inhibits | gene | 0.90 |
| mTOR | activates | protein | 0.90 |
| ULK1 | involved_in | protein | 0.90 |
| BECN1 | regulates | protein | 0.90 |
| RB1CC1 | involved_in | protein | 0.87 |
| MTOR | regulates | protein | 0.85 |
| ULK1 | upstream_of | gene | 0.85 |
| Selective Autophagy | mediates | process | 0.80 |
| ULK1 | initiates | gene | 0.70 |
| NBR1 | activates | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Chronic mTORC1-ULK1 signaling blocks autophagy initiation in | 0.578 | neurodegeneration | What specific autophagy pathways are def |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-08 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning autophagy initiation in their description or question text
No additional research found