gene

ZDHHC8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ZDHHC8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

22Outgoing

11Incoming

0Experiments

0Debates

Summary

Page for ZDHHC8 — Zinc Finger DHHC-Type Palmitoyltransferase 8

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🧬 Gene Info

Gene Symbol	ZDHHC8
Full Name	Zinc Finger DHHC-Type Palmitoyltransferase 8
Chromosome	22q11.21
Protein Type	Enzyme
Function	is a critical enzyme that catalyzes S-acylation (palmitoylation) of proteins, a reversible post-translational modification essential for protein trafficking, localization, and function in neurons.
Primary Expression	Brain (Cortex, Hippocampus, Cerebellum), Neurons
Pathways	Ferroptosis
UniProt ID	Q9NXK5
NCBI Gene ID	57103
Ensembl ID	ENSG00000140995
OMIM	611415
GeneCards	ZDHHC8
Human Protein Atlas	ZDHHC8
Associated Diseases	Cancer, ferroptosis
Known Drugs/Compounds	PF-670462
Interactions	AGING, AND, CANCER, CD8, FERROPTOSIS, Fus
KG Connections	33 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ZDHHC8 — AlphaFold Q9NXK5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ZDHHC8 — Zinc Finger DHHC-Type Palmitoyltransferase 8

gene · 1236 words

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Pathway Diagram

graph TD
    ZDHHC8["ZDHHC8"]
    GPX4["GPX4"]
    ZDHHC8 -->|"modifies"| GPX4
    ferroptosis["ferroptosis"]
    ZDHHC8 -->|"inhibits"| ferroptosis
    Aging{"Aging"}
    ZDHHC8 -->|"inhibits"| Aging
    Neurodegeneration{"Neurodegeneration"}
    ZDHHC8 -->|"inhibits"| Neurodegeneration
    Cancer{"Cancer"}
    ZDHHC8 -->|"inhibits"| Cancer
    Ischemia{"Ischemia"}
    ZDHHC8 -->|"inhibits"| Ischemia
    Ms{"Ms"}
    ZDHHC8 -->|"inhibits"| Ms
    Tumor{"Tumor"}
    ZDHHC8 -->|"expressed in"| Tumor
    CD8["CD8"]
    ZDHHC8 -->|"inhibits"| CD8
    FERROPTOSIS["FERROPTOSIS"]
    ZDHHC8 -->|"activates"| FERROPTOSIS
    CANCER["CANCER"]
    ZDHHC8 -->|"inhibits"| CANCER
    ZDHHC8 -->|"activates"| GPX4
    PF_670462["PF-670462"]
    PF_670462 -->|"inhibits"| ZDHHC8
    AGING["AGING"]
    AGING -->|"inhibits"| ZDHHC8
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"inhibits"| ZDHHC8
    style ZDHHC8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (22)

Target	Relation	Type	Str
GPX4	modifies	protein	0.90
Cancer	associated_with	disease	0.85
GPX4	palmitoylates	protein	0.80
ferroptosis	inhibits	phenotype	0.80
Cancer	inhibits	disease	0.65
Ischemia	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Tumor	expressed_in	disease	0.65
Aging	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
CANCER	inhibits	gene	0.60
FERROPTOSIS	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
NEURODEGENERATION	inhibits	gene	0.60
AND	activates	gene	0.60
AGING	inhibits	gene	0.60
CD8	inhibits	gene	0.60
GPX4	activates	gene	0.60
Ras	expressed_in	protein	0.60
Fus	inhibits	protein	0.60
ferroptosis	associated_with	phenotype	0.50
ferroptosis	activates	phenotype	0.50

Incoming (11)

Source	Relation	Type	Str
PF-670462	inhibits	drug	0.90
PF-670462	promotes	drug	0.90
PF-670462	degrades	compound	0.80
AGING	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
FERROPTOSIS	activates	gene	0.60
CD8	inhibits	gene	0.60
GPX4	associated_with	gene	0.50
GPX4	expressed_in	gene	0.50
GPX4	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ZDHHC8 in their description or question text

No additional research found