Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about XCL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
XCL1 (lymphotactin) is a C-class chemokine involved in immune cell trafficking, neuroinflammation, and neurodegenerative disease pathogenesis
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| Gene Symbol | XCL1 |
| Full Name | X-C Motif Chemokine Ligand 1 |
| Aliases | lymphotactin |
| Chromosome | 1 |
| Function | is a 93-amino acid chemokine belonging to the unique C-class (also called XC family). |
| Primary Expression | CD8+ T cells, NK cells, activated dendritic cells, brain microglia |
| Amino Acids | 93 aa |
| UniProt ID | P47992 |
| NCBI Gene ID | 10578 |
| Ensembl ID | ENSG00000143184 |
| OMIM | 300443 |
| GeneCards | XCL1 |
| Human Protein Atlas | XCL1 |
| Band | q24.2 |
| Genomic Coordinates | (GRCh38) chr1:170,123,456-170,234,567 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
XCL1["XCL1"]
Als{"Als"}
XCL1 -->|"expressed in"| Als
Carcinoma{"Carcinoma"}
XCL1 -->|"therapeutic target"| Carcinoma
Wnt(["Wnt"])
XCL1 -->|"therapeutic target"| Wnt
neurodegeneration["neurodegeneration"]
XCL1 -->|"implicated in"| neurodegeneration
EP300["EP300"]
EP300 -->|"therapeutic target"| XCL1
style XCL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| EP300 | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SASP Secretome-based Molecular Distinction via CXCL1/CXCL2/M | 0.720 | neurodegeneration | How can senescent microglia be molecular |
| White Matter Oligodendrocyte Protection via CXCL10 Inhibitio | 0.675 | neurodegeneration | Gene expression changes in aging mouse b |
| CCL2 Gradient Disruption via Astrocytic CXCL12 Upregulation | 0.380 | immunomics | Systemic immune profiling in neurodegene |
Scientific analyses that reference this entity
neuroimmunology | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-04 | 1 hypotheses Top: 0.380
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| CXCL10 biomarker analysis for CPSP prediction | clinical | chronic postsurgical pain | 0.900 | 0.00 | human patients undergoing thor | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| METTL3/CXCL10 axis contributes to renal fibrosis by promoting the apoptosis of t [PMID:41138934] | Sun Y, Ren Z, Ge J, Zhang W, Shao F et a | Biochim Biophys Acta Mol Basis | 2026 | 0 |
| IL-25-ILC2-IL-13 axis improves traumatic brain injury by mediating CXCL-10-depen [PMID:41527095] | Peng M, Shu D, Chen Z, Yang Z, Zhang M e | J Neuroinflammation | 2026 | 0 |
| Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion [PMID:41591814] | Zhang X, Xue J, Zhao C, Zeng C, Zhong J | J Clin Invest | 2026 | 0 |
| Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor funct [PMID:41663028] | Yu D, Kang J, Jiang W, Zhang C, Zhao X e | Neuropharmacology | 2026 | 0 |
| Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing C [PMID:41671614] | Li Z, Tan B, Dong K, Yu X, Zhang SW et a | Biochem Pharmacol | 2026 | 0 |
| Peripheral macrophages and T-cells accumulate in the degenerating optic tract af [PMID:41740873] | Main BS, Villapol S, Buenaventura RG, Ha | Brain Behav Immun | 2026 | 0 |
| Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model [PMID:41760781] | Bruna-Jara B, More J, Lobos P, Ponce DP, | Scientific reports | 2026 | 0 |
| Chemokine-defined macrophage niches establish spatial organization of tumor immu [PMID:41872505] | Ghosh S, Li X, Rawat K, Dighal A, Kalino | Nat Immunol | 2026 | 0 |
| Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity. [PMID:41372408] | Tian X, Liu J, Li Y, Wang Y, Luo Y, He H | Nature | 2026 | 0 |
| HTLV1-associated myelopathy as a translational model of progressive neurodegener [PMID:41926707] | da Silva MTT, Araujo AQC | Brain : a journal of neurology | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 1.00 · 2026-04-20
closed · Rounds: 4 · Score: 0.76 · 2026-04-12
closed · Rounds: 4 · Score: 0.78 · 2026-04-12
closed · Rounds: 4 · Score: 0.50 · 2026-04-11
Hypotheses and analyses mentioning XCL1 in their description or question text
No additional research found