gene

TMEM55B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TMEM55B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

14Outgoing

4Incoming

0Experiments

0Debates

No summary available yet.

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🧬 Gene Info

Gene Symbol	TMEM55B
Full Name	Transmembrane Protein 55B
Chromosome	14q11.2
Function	is a gene on chromosome 14q11.
Primary Expression	Brain, Substantia Nigra, lysosomal compartments
Subcellular Localization	endolysosomal membranes where it regulates phosphatidylinositol (PI) signaling and lysosomal function
Amino Acids	277 aa
UniProt ID	Q86T03
NCBI Gene ID	90809
Ensembl ID	ENSG00000100889
OMIM	609865
GeneCards	TMEM55B
Human Protein Atlas	TMEM55B
Associated Diseases	Alzheimer's Disease, BMD
Interactions	JIP4, LRRK2, WDR81
KG Connections	18 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TMEM55B — AlphaFold Q86T03 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TMEM55B — Transmembrane Protein 55B

gene · 2210 words

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Pathway Diagram

graph TD
    TMEM55B["TMEM55B"]
    CTNS["CTNS"]
    TMEM55B -->|"regulates"| CTNS
    LDLR["LDLR"]
    TMEM55B -->|"regulates"| LDLR
    V_ATPase["V-ATPase"]
    TMEM55B -->|"contributes to"| V_ATPase
    mTORC1["mTORC1"]
    TMEM55B -->|"activates"| mTORC1
    lipid_metabolism["lipid_metabolism"]
    TMEM55B -->|"modulates"| lipid_metabolism
    BMD["BMD"]
    TMEM55B -->|"associated with"| BMD
    phosphatases["phosphatases"]
    TMEM55B -->|"upregulates"| phosphatases
    neurodegeneration["neurodegeneration"]
    TMEM55B -->|"implicated in"| neurodegeneration
    TFEB["TFEB"]
    TFEB -->|"upregulates"| TMEM55B
    style TMEM55B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (14)

Target	Relation	Type	Str
PLEKHM1	associated_with	protein	0.80
FLCN/FNIP complex	associated_with	entity	0.80
LDLR	regulates	protein	0.80
CTNS	regulates	protein	0.80
V-ATPase	contributes_to	entity	0.70
mTORC1	activates	entity	0.70
ESCRT machinery	associated_with	entity	0.70
CTNS	associated_with	protein	0.70
V-ATPase complex	associated_with	entity	0.70
oxidative stress response	participates_in	pathway	0.60
Alzheimer's Disease	associated_with	disease	0.60
BMD	associated_with	phenotype	0.60
phosphatases	upregulates	enzyme	0.60
WDR81	interacts_with	gene	0.60

Incoming (4)

Source	Relation	Type	Str
VPS35[D620N]	associated_with	entity	0.80
JIP4	inhibits	gene	0.70
LRRK2	phosphorylates	protein	0.70
JIP4	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TMEM55B in their description or question text

No additional research found