Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CTNS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Gene Symbol | CTNS |
| Function | It functions as an H⁺-driven cystine symporter, coupling the efflux of cystine from the lysosomal lumen to proton import[1] |
| Subcellular Localization | to the lysosomal membrane |
| Amino Acids | 367 aa |
| Pathways | mTOR, mtor |
| Ensembl ID | ENSG00000040531 |
| GeneCards | CTNS |
| Human Protein Atlas | CTNS |
| Cystine Export | Transports the disulfide amino acid cystine (oxidized form of cysteine) out of lysosomes |
| Proton Coupling | Uses the lysosomal proton gradient (maintained by v-ATPase) as driving force |
| Redox Balance | By exporting cystine for reduction to cysteine in the cytosol, supports cellular glutathione synthesis |
| Lysosomal Homeostasis | Prevents cystine crystal accumulation that damages lysosomal membranes |
| Seven transmembrane domains | Form the transport channel for cystine |
| Lysosomal targeting motifs | GYDQL sequence in the C-terminal tail directs protein to lysosomes |
| N-glycosylation sites | Seven N-linked glycosylation sites in the intralysosomal loops |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CTNS["CTNS"]
TMEM55B["TMEM55B"]
neurodegeneration["neurodegeneration"]
TMEM55B -->|"regulates"| CTNS
TMEM55B -->|"associated with"| CTNS
CTNS -->|"implicated in"| neurodegeneration
style CTNS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style TMEM55B fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CTNS in their description or question text
No additional research found