gene

SLC11A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC11A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

12Outgoing

5Incoming

0Experiments

0Debates

Summary

Divalent metal transporter (NRAMP1) with critical roles in microglia function, neuroinflammation, and metal homeostasis in neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	SLC11A1
Aliases	NRAMP1
Chromosome	2q35
Protein Type	Transporter
Function	encodes a divalent metal transporter that plays critical roles in iron and manganese homeostasis, macrophage activation, and neuroinflammatory responses.
Primary Expression	microglia and peripheral macrophages, where it regulates intracellular metal concentrations and modulates inflammatory responses
Molecular Weight	55 kDa
Amino Acids	550 aa
Exons	15
Ensembl ID	ENSG00000008080
GeneCards	SLC11A1
Human Protein Atlas	SLC11A1
N-terminal region	Intracellular loop containing targeting motifs
Transmembrane helices 1-10	Form the transport channel
C-terminal region	Intracellular domain with regulatory functions
Associated Diseases	neurodegeneration
KG Connections	17 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC11A1

gene · 1752 words

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Pathway Diagram

graph TD
    SLC11A1["SLC11A1"]
    Diabetes{"Diabetes"}
    SLC11A1 -->|"therapeutic target"| Diabetes
    Obesity{"Obesity"}
    SLC11A1 -->|"therapeutic target"| Obesity
    Als{"Als"}
    SLC11A1 -->|"therapeutic target"| Als
    Ms{"Ms"}
    SLC11A1 -->|"biomarker for"| Ms
    Metabolic_Syndrome{"Metabolic Syndrome"}
    SLC11A1 -->|"therapeutic target"| Metabolic_Syndrome
    Ferroptosis(["Ferroptosis"])
    SLC11A1 -->|"biomarker for"| Ferroptosis
    TLR7["TLR7"]
    SLC11A1 -->|"biomarker for"| TLR7
    FERROPTOSIS["FERROPTOSIS"]
    SLC11A1 -->|"biomarker for"| FERROPTOSIS
    PPARGC1A["PPARGC1A"]
    SLC11A1 -->|"biomarker for"| PPARGC1A
    ERN1["ERN1"]
    SLC11A1 -->|"biomarker for"| ERN1
    neurodegeneration["neurodegeneration"]
    SLC11A1 -->|"implicated in"| neurodegeneration
    GENES["GENES"]
    GENES -->|"therapeutic target"| SLC11A1
    ERN1 -->|"biomarker for"| SLC11A1
    TLR7 -->|"biomarker for"| SLC11A1
    PPARGC1A -->|"biomarker for"| SLC11A1
    MYC["MYC"]
    MYC -->|"biomarker for"| SLC11A1
    style SLC11A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

Target	Relation	Type	Str
Neuroinflammation	promotes	process	0.85
Neuroinflammation	contributes_to	process	0.75
Diabetes	therapeutic_target	disease	0.65
Obesity	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	biomarker_for	disease	0.65
Metabolic Syndrome	therapeutic_target	disease	0.65
Ferroptosis	biomarker_for	pathway	0.60
FERROPTOSIS	biomarker_for	gene	0.60
TLR7	biomarker_for	gene	0.60
PPARGC1A	biomarker_for	gene	0.60
ERN1	biomarker_for	gene	0.60

Incoming (5)

Source	Relation	Type	Str
GENES	therapeutic_target	gene	0.60
ERN1	biomarker_for	gene	0.60
TLR7	biomarker_for	gene	0.60
PPARGC1A	biomarker_for	gene	0.60
MYC	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC11A1 in their description or question text

No additional research found