Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ST3GAL2/ST8SIA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Name | ST3GAL2/ST8SIA1 |
| Key Genes/Proteins | ABCA1/LDLR/SREBF2, BACE1, CYP46A1, FLOT1, SGMS1, SGMS1/SGMS2 |
| Related Diseases | neurodegeneration |
| Related Pathways | sphingolipid___ceramide_signaling |
graph TD
ST3GAL2_ST8SIA1[ST3GAL2/ST8SIA1]
ST3GAL2_ST8SIA1 -->|implicated in| neurodegeneration[neurodegeneration]
ST3GAL2_ST8SIA1 -->|involved_in| sphingolipid___ceramide_signal[sphingolipid___ceramide_signaling]
ST3GAL2_ST8SIA1 -->|data_in| benchmark_ot_ad_answer_key_ST3[benchmark_ot_ad_answer_key:ST3GAL2/ST8SIA1]
h_12599989[h-12599989] -->|targets| ST3GAL2_ST8SIA1
SGMS1[SGMS1] -->|debate_co_mention| ST3GAL2_ST8SIA1
SGMS1_SGMS2[SGMS1/SGMS2] -->|debate_co_mention| ST3GAL2_ST8SIA1
SMPD1[SMPD1] -->|debate_co_mention| ST3GAL2_ST8SIA1
ST3GAL2[ST3GAL2] -->|debate_co_mention| ST3GAL2_ST8SIA1
CYP46A1[CYP46A1] -->|co_associated_with| ST3GAL2_ST8SIA1
BACE1[BACE1] -->|co_associated_with| ST3GAL2_ST8SIA1
ABCA1_LDLR_SREBF2[ABCA1/LDLR/SREBF2] -->|co_associated_with| ST3GAL2_ST8SIA1
FLOT1[FLOT1] -->|co_associated_with| ST3GAL2_ST8SIA1| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ST3GAL2/ST8SIA1 | data_in | dataset_row | 0.00 |
| sphingolipid___ceramide_signaling | involved_in | pathway | 0.40 |
| neurodegeneration | associated_with | disease | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ST3GAL2/ST8SIA1 | data_in | dataset_row | 0.00 |
| h-12599989 | targets | hypothesis | 0.50 |
| SGMS1/SGMS2 | debate_co_mention | gene | 0.45 |
| SMPD1 | debate_co_mention | gene | 0.45 |
| ST3GAL2 | debate_co_mention | gene | 0.45 |
| SGMS1 | debate_co_mention | gene | 0.45 |
| CYP46A1 | co_associated_with | gene | 0.40 |
| BACE1 | co_associated_with | gene | 0.40 |
| ABCA1/LDLR/SREBF2 | co_associated_with | gene | 0.40 |
| FLOT1 | co_associated_with | gene | 0.40 |
| SGMS1/SGMS2 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Ganglioside Rebalancing Therapy | 0.690 | neurodegeneration | Lipid raft composition changes in synapt |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.921
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Oligodendrocyte-Myelin Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Genetic variants in ganglioside synthesis enzymes associate with Alzheimer's dis [PMID:synthetic_29] | Unknown | Nat Genet | 2024 | 0 |
| CSF ganglioside ratios predict Alzheimer's disease progression and correlate wit [PMID:synthetic_27] | Unknown | JAMA Neurol | 2023 | 0 |
| Small-molecule modulation of ganglioside synthesis normalizes brain lipid compos [PMID:synthetic_26] | Unknown | Nat Neurosci | 2023 | 0 |
| Glycosphingolipid-Glycan Signatures of Acute Myeloid Leukemia Cell Lines Reflect [PMID:35168327] | ["Wang D", "Zhang T", "Maduni\u0107 K", | Journal of proteome research | 2022 | 0 |
| Brain ganglioside composition is dysregulated in Alzheimer's disease with GM1 de [PMID:synthetic_24] | Unknown | Ann Neurol | 2022 | 0 |
| GM1 enhances BDNF-TrkB signaling and neuroprotection via lipid raft organization [PMID:synthetic_28] | Unknown | Mol Psychiatry | 2022 | 0 |
| Ganglioside composition varies widely across brain regions and cell types [PMID:synthetic_32] | Unknown | J Lipid Res | 2021 | 0 |
| Exogenous GM1 administration improves cognition and reduces pathology in APP/PS1 [PMID:synthetic_25] | Unknown | Neurobiol Aging | 2020 | 0 |
| Exogenous GM1 shows limited CNS bioavailability in clinical trials for Parkinson [PMID:synthetic_30] | Unknown | Mov Disord | 2019 | 0 |
| Ganglioside synthesis inhibitors cause peripheral neuropathy in Gaucher disease [PMID:synthetic_31] | Unknown | Ann Neurol | 2018 | 0 |
| Dynamism in gene expression across multiple studies. [PMID:19920211] | ["Morgan A", "Dudley J", "Deshpande T", | Physiological genomics | 2010 | 0 |
| Mutations in desmoglein-2 gene are associated with arrhythmogenic right ventricu [PMID:16505173] | ["Pilichou K", "Nava A", "Basso C", "Bef | Circulation | 2006 | 0 |
| Epidermal growth factor receptor as a therapeutic target in human thyroid carcin [PMID:16822827] | ["Mitsiades C", "Kotoula V", "Poulaki V" | The Journal of clinical endocr | 2006 | 0 |
| Re: Use of an Amplatz Goose Neck Snare as a Target for Collateral Neck Vein Dial [PMID:11585895] | Funaki B; Zaleski G X | Journal of Vascular and Interv | 2001 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning ST3GAL2/ST8SIA1 in their description or question text
No additional research found