Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ABCA1/LDLR/SREBF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ABCA1/LDLR/SREBF2 |
| Key Genes/Proteins | ABCA1, BACE1, CYP46A1, FLOT1, LDLR, SGMS1/SGMS2 |
| Related Diseases | neurodegeneration |
| Related Pathways | cholesterol_efflux___lipid_transport |
graph TD
ABCA1_LDLR_SREBF2[ABCA1/LDLR/SREBF2]
ABCA1_LDLR_SREBF2 -->|debate_co_mention| BACE1[BACE1]
ABCA1_LDLR_SREBF2 -->|debate_co_mention| CYP46A1[CYP46A1]
ABCA1_LDLR_SREBF2 -->|debate_co_mention| FLOT1[FLOT1]
ABCA1_LDLR_SREBF2 -->|debate_co_mention| LDLR[LDLR]
ABCA1_LDLR_SREBF2 -->|implicated in| neurodegeneration[neurodegeneration]
ABCA1_LDLR_SREBF2 -->|co_associated_with| SGMS1_SGMS2[SGMS1/SGMS2]
ABCA1_LDLR_SREBF2 -->|co_associated_with| ST3GAL2_ST8SIA1[ST3GAL2/ST8SIA1]
h_9d29bfe5[h-9d29bfe5] -->|targets| ABCA1_LDLR_SREBF2
ABCA1[ABCA1] -->|debate_co_mention| ABCA1_LDLR_SREBF2
benchmark_ot_ad_answer_key_ABC[benchmark_ot_ad_answer_key:ABCA1/LDLR/SREBF2] -->|data_in| ABCA1_LDLR_SREBF2| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ABCA1/LDLR/SREBF2 | data_in | dataset_row | 0.00 |
| CYP46A1 | debate_co_mention | gene | 0.45 |
| FLOT1 | debate_co_mention | gene | 0.45 |
| LDLR | debate_co_mention | gene | 0.45 |
| BACE1 | debate_co_mention | gene | 0.45 |
| FLOT1 | co_associated_with | gene | 0.40 |
| SGMS1/SGMS2 | co_associated_with | gene | 0.40 |
| BACE1 | co_associated_with | gene | 0.40 |
| CYP46A1 | co_associated_with | gene | 0.40 |
| ST3GAL2/ST8SIA1 | co_associated_with | gene | 0.40 |
| cholesterol_efflux___lipid_transport | involved_in | pathway | 0.40 |
| neurodegeneration | associated_with | disease | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ABCA1/LDLR/SREBF2 | data_in | dataset_row | 0.00 |
| h-9d29bfe5 | targets | hypothesis | 0.50 |
| ABCA1 | debate_co_mention | gene | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Membrane Cholesterol Gradient Modulators | 0.708 | neurodegeneration | Lipid raft composition changes in synapt |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.921
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Metal Ion Homeostasis Dysregulation in Alzheimer's Disease | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704] | Zhang T, Xu D, Trefts E, Lv M, Inuzuka H | Science | 2023 | 1 |
| TREM2, microglia, and Alzheimer's disease. [PMID:33516818] | Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang | Mech Ageing Dev | 2021 | 1 |
| Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK [PMID:31693892] | Wang Y, An H, Liu T, Qin C, Sesaki H, Gu | Cell Rep | 2019 | 1 |
| TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038] | Ulland TK, Song WM, Huang SC, Ulrich JD, | Cell | 2017 | 1 |
| The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974] | Dai L, Wang J, Meng L, Zhang X, Xiao T, | PLoS biology | 2025 | 0 |
| Development of Injectable Thermosensitive Nanocomposite Hydrogel for Ratiometric [PMID:38456789] | ["Zhu J", "Wei R", "Hu G", "Wang H", "Wa | Small (Weinheim an der Bergstr | 2024 | 0 |
| RNA-Independent Regulatory Functions of lncRNA in Complex Disease. [PMID:39123456] | ["Kafida M", "Karela M", "Giakountis A"] | Cancers | 2024 | 0 |
| Raccoon eyes [PMID:35789012] | Ning Junjie | Journal of Paediatrics and Chi | 2023 | 0 |
| Isolated Trapeziometacarpal Joint Dislocation With Five Years of Follow-up: A Ca [PMID:36891023] | ["Missaoui Z", "Moussa M", "Boushnak M", | Cureus | 2023 | 0 |
| Exploring factors associated with preferences for human papillomavirus (HPV) sel [PMID:37234567] | ["Xiong S", "Ghebre R", "Kulasingam S", | Preventive medicine reports | 2023 | 0 |
| Patient's Knowledge and Perception of Endodontics Treatment: An Observational St [PMID:37654321] | ["Manasa N", "Naik K", "Singh M", "Moiz | Journal of pharmacy & bioallie | 2023 | 0 |
| Photosynthetic acclimation to changing environments. [PMID:36892145] | ["Gjindali A", "Johnson G"] | Biochemical Society transactio | 2023 | 0 |
| Antiviral, immunomodulatory, and anticoagulant effects of quercetin and its deri [PMID:34567823] | ["Manjunath S", "Thimmulappa R"] | Journal of pharmaceutical anal | 2022 | 0 |
| ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheim [PMID:35236834] | Zhao Y, Hu D, Wang R, Sun X, Ropelewski | Nature communications | 2022 | 0 |
| Comparative study of haemodynamic effects of intravenous ketamine-fentanyl and p [PMID:35102948] | ["Okeyemi A", "Suleiman A", "Oyedepo O", | The Nigerian postgraduate medi | 2022 | 0 |
| TREM2, microglia, and Alzheimer's disease. [PMID:33516818] | Qin Q, Teng Z, Liu C, Li Q, Yin Y et al. | Mech Ageing Dev | 2021 | 0 |
| Ambulatory Care Sensitive Conditions in Pediatrics: Time for a Reassessment. [PMID:34215678] | Sam Lu | Pediatrics | 2021 | 0 |
| Deep anaesthesia. [PMID:32891204] | Salome Dell-Kuster; Luzius A Steiner; Ji | Lancet (London, England) | 2020 | 0 |
| Comparison Between Biomarkers of Kidney Injury, Inflammation, and Oxidative Stre [PMID:32156839] | Aghadavod E, Soleimani A, Amirani E, Gho | Iranian journal of kidney dise | 2020 | 0 |
| Electrochemiluminescence on smartphone with silica nanopores membrane modified e [PMID:30245166] | ["Li S", "Zhang D", "Liu J", "Cheng C", | Biosensors & bioelectronics | 2019 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning ABCA1/LDLR/SREBF2 in their description or question text
No additional research found