gene

SCFD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCFD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

13Outgoing

4Incoming

0Experiments

0Debates

Summary

SCFD1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, upregulates. Associated with Aging, Ms. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SCFD1
Chromosome	9q34.3
Function	is a member of the Sec1/Munc18 (SM) protein family that plays essential roles in intracellular vesicle trafficking and membrane fusion events throughout the cell.
Primary Expression	both excitatory glutamatergic and inhibitory GABAergic neurons - Present in astrocytes and oligodendrocytes - High expression
Molecular Weight	41 kDa
Amino Acids	372 aa
Exons	14
Ensembl ID	ENSG00000084112
GeneCards	SCFD1
Human Protein Atlas	SCFD1
Sedlin	Named after the Sedlis syndrome (a form of spondylometaphyseal dysplasia)
Sly1	Suppressor of ypt1 in yeast
KIAA0822	Formerly used identifier
Sec1 domain	~300 amino acid conserved SM protein fold
N-terminal peptide-binding groove	Binds to SNARE motifs
Associated Diseases	Ms
Interactions	AGING, AMPK, EXERCISE, JAK2, KDM5D
KG Connections	17 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SCFD1

gene · 1061 words

→

SCFD1 Protein

protein · 619 words

→

Pathway Diagram

graph TD
    SCFD1["SCFD1"]
    TREM2["TREM2"]
    SCFD1 -->|"upregulates"| TREM2
    Aging{"Aging"}
    SCFD1 -->|"interacts with"| Aging
    Ms{"Ms"}
    SCFD1 -->|"associated with"| Ms
    JAK2["JAK2"]
    SCFD1 -->|"interacts with"| JAK2
    AKT["AKT"]
    SCFD1 -->|"associated with"| AKT
    KDM5D["KDM5D"]
    SCFD1 -->|"interacts with"| KDM5D
    APOPTOSIS["APOPTOSIS"]
    SCFD1 -->|"associated with"| APOPTOSIS
    FOXO1["FOXO1"]
    SCFD1 -->|"associated with"| FOXO1
    EXERCISE["EXERCISE"]
    SCFD1 -->|"interacts with"| EXERCISE
    Apoptosis(["Apoptosis"])
    SCFD1 -->|"associated with"| Apoptosis
    Akt(["Akt"])
    SCFD1 -->|"associated with"| Akt
    Immune_Response(["Immune Response"])
    SCFD1 -->|"associated with"| Immune_Response
    OxPC["OxPC"]
    OxPC -->|"causes"| SCFD1
    microglia["microglia"]
    microglia -->|"binds"| SCFD1
    AGING["AGING"]
    AGING -->|"interacts with"| SCFD1
    style SCFD1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (13)

Target	Relation	Type	Str
SNARE complex formation	modulates	process	0.90
TREM2	upregulates	gene	0.80
Ms	associated_with	disease	0.65
Aging	interacts_with	disease	0.65
APOPTOSIS	associated_with	gene	0.60
JAK2	interacts_with	gene	0.60
AKT	associated_with	gene	0.60
KDM5D	interacts_with	gene	0.60
FOXO1	associated_with	gene	0.60
Immune Response	associated_with	pathway	0.60
EXERCISE	interacts_with	gene	0.60
Apoptosis	associated_with	pathway	0.60
Akt	associated_with	pathway	0.60

Incoming (4)

Source	Relation	Type	Str
AMPK	phosphorylates	protein	0.95
microglia	binds	cell_type	0.70
OxPC	causes	chemical	0.70
AGING	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SCFD1 in their description or question text

No additional research found