concept

RUTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RUTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

3Hypotheses

1Analyses

19Outgoing

0Incoming

0Experiments

1Debates

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💡 Concept Info

Name	RUTIN
Key Genes/Proteins	IL-1β, TNF-α

Pathway Diagram

graph TD
    RUTIN[RUTIN]
    RUTIN -->|inhibits| IL6[IL6]
    RUTIN -->|inhibits| AGE_RAGE_pathway[AGE-RAGE pathway]
    RUTIN -->|inhibits| TAU[TAU]
    RUTIN -->|inhibits| TNF__[TNF-α]
    RUTIN -->|downregulates| TNF[TNF]
    RUTIN -->|downregulates| Il_1_[Il-1Β]
    RUTIN -->|inhibits| Neuroinflammation[Neuroinflammation]
    RUTIN -->|treats| psoriasis[psoriasis]
    RUTIN -->|treats| ALZHEIMER_S_DISEASE[ALZHEIMER'S DISEASE]
    RUTIN -.protects against.-> Neuron[Neuron]

Outgoing (19)

Target	Relation	Type	Str
AGE-RAGE pathway	inhibits	pathway	0.90
IL6	inhibits	protein	0.90
TNF-α	inhibits	protein	0.90
TAU	inhibits	protein	0.90
TNF	downregulates	protein	0.85
Il-1Β	downregulates	protein	0.85
Neuroinflammation	inhibits	process	0.85
ALZHEIMER'S DISEASE	treats	disease	0.80
Neuron	protects_against	cell_type	0.80
psoriasis	treats	disease	0.80
IL-1β	inhibits	protein	0.70
TNF-α	inhibits	protein	0.70
tau	inhibits	protein	0.70
TNF	inhibits	protein	0.70
neuroinflammation	protects_against	process	0.70
tau_aggregation	inhibits	process	0.70
MAPT	modulates	gene	0.70
autophagy_pathway	activates	pathway	0.70
redox_active_metals	inhibits	biomarker	0.50

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Rutin stabilizes a non-nucleating tau conformer through dire	0.627	neurodegeneration	What is the molecular mechanism by which
Rutin reduces ROS- and metal-driven tau oligomer nucleation	0.602	neurodegeneration	What is the molecular mechanism by which
Rutin enhances chaperone and autophagic clearance of misfold	0.599	neurodegeneration	What is the molecular mechanism by which

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the molecular mechanism by which rutin inhibits tau aggregation and olig

neurodegeneration | 2026-04-25 | 3 hypotheses Top: 0.627

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What is the molecular mechanism by which rutin inhibits tau aggregation and olig

closed · Rounds: 4 · Score: 0.66 · 2026-04-25

Related Research

Hypotheses and analyses mentioning RUTIN in their description or question text

No additional research found