gene

RPL27A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPL27A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

0Analyses

8Outgoing

4Incoming

0Experiments

0Debates

Summary

RPL27A is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, interacts with, implicated in. Associated with Cancer, Epilepsy, Ms. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RPL27A
Full Name	Ribosomal Protein L27A
Chromosome	16p13.3
Function	encodes a component of the large 60S ribosomal subunit, essential for protein synthesis in all eukaryotic cells.
Primary Expression	neurons and glia throughout the brain and spinal cord
Molecular Weight	16.7 kDa
Amino Acids	158 aa
Exons	6
UniProt ID	P46776
NCBI Gene ID	6163
Ensembl ID	ENSG00000265391
GeneCards	RPL27A
Human Protein Atlas	RPL27A
Associated Diseases	neurodegeneration
Interactions	EIF4G2
KG Connections	12 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RPL27A — AlphaFold P46776 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RPL27A — Ribosomal Protein L27A

gene · 2204 words

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Pathway Diagram

graph TD
    RPL27A["RPL27A"]
    Epilepsy{"Epilepsy"}
    RPL27A -->|"therapeutic target"| Epilepsy
    Cancer{"Cancer"}
    RPL27A -->|"therapeutic target"| Cancer
    Tumor{"Tumor"}
    RPL27A -->|"therapeutic target"| Tumor
    Ms{"Ms"}
    RPL27A -->|"therapeutic target"| Ms
    Oxidative_Stress(["Oxidative Stress"])
    RPL27A -->|"therapeutic target"| Oxidative_Stress
    Wnt(["Wnt"])
    RPL27A -->|"therapeutic target"| Wnt
    CANCER["CANCER"]
    RPL27A -->|"therapeutic target"| CANCER
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    RPL27A -->|"therapeutic target"| OXIDATIVE_STRESS
    neurodegeneration["neurodegeneration"]
    RPL27A -->|"implicated in"| neurodegeneration
    EIF4G2["EIF4G2"]
    EIF4G2 -->|"interacts with"| RPL27A
    KIF2A["KIF2A"]
    KIF2A -->|"therapeutic target"| RPL27A
    GENES["GENES"]
    GENES -->|"therapeutic target"| RPL27A
    DNA["DNA"]
    DNA -->|"therapeutic target"| RPL27A
    style RPL27A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
Epilepsy	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Oxidative Stress	therapeutic_target	pathway	0.60
Wnt	therapeutic_target	pathway	0.60
CANCER	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60

Incoming (4)

Source	Relation	Type	Str
EIF4G2	interacts_with	gene	0.70
KIF2A	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RPL27A in their description or question text

No additional research found