entity

RAC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

30Hypotheses

0Analyses

2Outgoing

1Incoming

0Experiments

0Debates

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Wiki Pages (5)

Knowledge base pages for this entity

Outgoing (2)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:RAC	data_in	dataset_row	0.00
neurodevelopmental disorders	implicated_in	disease	0.70

Incoming (1)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:RAC	data_in	dataset_row	0.00

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Plasma NfL Elevation Secondary to BBB-Associated Transport D	0.940	-	What blood-brain barrier permeability ch
ATM Kinase Hyperactivation Triggers DNA Damage Response Over	0.842	ALS	-
Extracellular Vesicle Biogenesis Modulation	0.814	neurodegeneration	Tau propagation mechanisms and therapeut
Neutrophil Extracellular Trap (NET) Inhibition	0.806	-	Blood-brain barrier tight junction disru
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	Alzheimer's disease	Circuit-level neural dynamics in neurode

Sleep-Dependent Glymphatic Clearance Expands the Therapeutic	0.780	neurodegeneration	What is the therapeutic window between t
Enhancing Microglial Phagocytosis of Extracellular Tau via T	0.771	neuroscience	Trans-synaptic tau spreading and propaga
Hypothesis 3: HepaCAM-Containing Extracellular Vesicles	0.762	neurodegeneration	View
cGAS-STING Pathway Hyperactivation Mediates Tau Propagation	0.760	neurodegeneration	Gap 006 analysis (archived stub)
APOE4 astrocytes exhibit impaired cholesterol efflux via ABC	0.758	neuroscience	APOE4-driven lipid metabolism dysregulat
PD-Associated GWAS Variants in CTSO and CTSF Genes Create a	0.743	neurodegeneration	-
APOE-TREM2 Interaction Modulation	0.741	neurodegeneration	Mechanistic role of APOE in neurodegener
SCFA Deficiency Drives Microglial Hyperactivation via GPR43/	0.728	neurodegeneration	How does gut microbiome dysbiosis contri
TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimina	0.724	neurodegeneration	How do the seven novel ALS genes functio
Interfacial Lipid Mimetics to Disrupt Domain Interaction	0.723	neurodegeneration	APOE4 structural biology and therapeutic
VCP/p97 ATPase mutations impair extraction of ubiquitinated	0.720	neurodegeneration	What are the neuron-specific effects of
Plasma Claudin-5 Proteolytic Fragments Distinguish Paracellu	0.705	-	What blood-brain barrier permeability ch
Extracellular Matrix Stiffness Modulation	0.691	neurodegeneration	Microglia-astrocyte crosstalk amplificat
Pericyte Contractility Reset via Selective PDGFR-β Agonism	0.684	neurodegeneration	Perivascular spaces and glymphatic clear
PGE2–EP2–cAMP–PKA Axis Displaces Pathological Microglial Mem	0.681	neuroinflammation	What specific astrocyte-derived factors
TREM2 R47H variant synergizes with APOE4 to collapse microgl	0.681	neuroscience	APOE4-driven lipid metabolism dysregulat
RAB27A-dependent extracellular vesicle engineering for mitoc	0.674	neurodegeneration	Mitochondrial transfer between astrocyte
LPS-primed microglial trained immunity establishes persisten	0.670	neurodegeneration	Synaptic pruning by microglia in neurode
GFAP-Bearing Circulating Extracellular Vesicles Originating	0.665	-	What blood-brain barrier permeability ch
Chronic cGAS/STING Hyperactivation Drives Progressive Neurod	0.661	neuroinflammation	How does chronic cGAS/STING activation d
Parthenolide reduces tonic ADORA2A signaling by lowering inf	0.659	neuropharmacology	How does parthenolide specifically modul
Astrocyte IL-1β as Paracrine Mediator of Microglial Compleme	0.658	neuroinflammation	How does sevoflurane-induced NF-κB activ
Endothelial miR-181c-5p Upregulation Drives Claudin-5 Repres	0.645	-	What blood-brain barrier permeability ch
H7: mTOR Hyperactivity Blocks Autophagy, Permitting Tau Seed	0.640	neurodegeneration	Entorhinal cortex layer II vulnerability
TBK1 Loss Triggers Astrocyte-to-Neuron Senescence Propagatio	0.000	ALS	What are the mechanisms by which microgl

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Autophagy-exosome crosstalk in neurodegeneration: Mechanisms and therapeutic opp [PMID:41833626]	Sedighi S, Guan T, Michetti F	Pharmacol Ther	2026
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN [PMID:38712164]	Unknown		2025
The R136S mutation in the APOE3 gene confers resilience against tau pathology vi [PMID:40555238]	Unknown		2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer [PMID:39753133]	Hyde VR, Zhou C, Fernandez JR, Chatterje	Cell reports	2025
Neutrophil extracellular traps in central nervous system disorders: mechanisms, [PMID:40469282]	Qiao S, Yuan J, Zhang SC	Front Immunol	2025
NETosis in Alzheimer's Disease: Understanding the Role of Neutrophil Extracellul [PMID:41460435]	Rao R, Verma H, Gangwar P	Mol Neurobiol	2025
The expanding world of neuroscience. [PMID:39423798]	Unknown	Cell	2024
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senes [PMID:39353433]	Carling GK, Fan L, Foxe NR, Norman K, Wo	Neuron	2024
Integrating network pharmacology and transcriptomic omics reveals that akebia sa [PMID:38149910]	Gu L, Ye L, Chen Y	FASEB J	2024
Blood-brain crosstalk: the roles of neutrophils, platelets, and neutrophil extra [PMID:37500363]	Chou Ming-Li; Babamale Abdulkareem Olare	Trends in neurosciences	2023
Brain alarm by self-extracellular nucleic acids: from neuroinflammation to neuro [PMID:37550658]	Kunze R, Fischer S, Marti HH	J Biomed Sci	2023
Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflam [PMID:34782623]	["Jin Meihua", "Shiwaku Hiroki", "Tanaka	Nature communications	2021
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Recent Developments in Diabetic Retinal Neurodegeneration: A Literature Review. [PMID:34151902]	Unknown	J Diabetes Res	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCR [PMID:31223056]	Feng Q, Luo Y, Zhang XN, Yang XF, Hong X	Autophagy	2020
The interplay between aging-associated loss of protein homeostasis and extracell [PMID:31549445]	Guix FX	J Neurosci Res	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAC in their description or question text

Sleep-Dependent Glymphatic Clearance Expands the Therapeutic Window by Reducing

Score: 0.780 · neurodegeneration · 2026-04-22

## Mechanistic Overview Sleep-Dependent Glymphatic Clearance Expands the Therapeutic Window by Reducing Extracellular Ta

Enhancing Microglial Phagocytosis of Extracellular Tau via TREM2 Activation

Score: 0.771 · neuroscience · 2026-04-22

**Molecular Mechanism and Rationale** The triggering receptor expressed on myeloid cells 2 (TREM2) represents a critica

Hypothesis 3: HepaCAM-Containing Extracellular Vesicles

Score: 0.762 · neurodegeneration · 2026-04-17

## Mechanistic Overview Hypothesis 3: HepaCAM-Containing Extracellular Vesicles starts from the claim that modulating HE

cGAS-STING Pathway Hyperactivation Mediates Tau Propagation

Score: 0.760 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The cGAS-STING (cyclic GMP-AMP synthase - stimulator of interferon genes) pathway

APOE4 astrocytes exhibit impaired cholesterol efflux via ABCA1/ABCG1 transporter

Score: 0.758 · neuroscience · 2026-04-22

## Mechanistic Overview APOE4 astrocytes exhibit impaired cholesterol efflux via ABCA1/ABCG1 transporters, driving intra

APOE-TREM2 Interaction Modulation

Score: 0.741 · neurodegeneration · 2026-04-02

## Mechanistic Overview APOE-TREM2 Interaction Modulation starts from the claim that modulating TREM2 within the disease

SCFA Deficiency Drives Microglial Hyperactivation via GPR43/NF-κB Dysregulation

Score: 0.728 · neurodegeneration · 2026-04-26

Gut dysbiosis depletes butyrate-producing commensals (Faecalibacterium prausnitzii, Clostridium XIVa, Akkermansia mucini

TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimination Through Type I

Score: 0.724 · neurodegeneration · 2026-04-13

**Molecular Mechanism and Rationale** The molecular cascade underlying TBK1 loss-of-function-mediated synapse eliminati

Interfacial Lipid Mimetics to Disrupt Domain Interaction

Score: 0.723 · neurodegeneration · 2026-04-02

## Mechanistic Overview Interfacial Lipid Mimetics to Disrupt Domain Interaction starts from the claim that modulating A

VCP/p97 ATPase mutations impair extraction of ubiquitinated autophagy substrates

Score: 0.720 · neurodegeneration · 2026-04-21

## Mechanistic Overview VCP/p97 ATPase mutations impair extraction of ubiquitinated autophagy substrates, causing protea

Plasma Claudin-5 Proteolytic Fragments Distinguish Paracellular BBB Breakdown fr

Score: 0.705 · unknown disease · 2026-04-26

Claudin-5 is the most abundant tight junction protein in brain endothelial cells and is specifically degraded during ear

Extracellular Matrix Stiffness Modulation

Score: 0.691 · neurodegeneration · 2026-04-02

## Mechanistic Overview Extracellular Matrix Stiffness Modulation starts from the claim that modulating PIEZO1 within th

Pericyte Contractility Reset via Selective PDGFR-β Agonism

Score: 0.684 · neurodegeneration · 2026-04-02

## Mechanistic Overview Pericyte Contractility Reset via Selective PDGFR-β Agonism starts from the claim that modulating

PGE2–EP2–cAMP–PKA Axis Displaces Pathological Microglial Memory Traces

Score: 0.681 · neuroinflammation · 2026-04-26

Astrocyte-produced PGE2 (via COX2 induction) engages microglial EP2 receptors, elevating cAMP and activating PKA. PKA ph

RAC