Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about POLYUNSATURATED FATTY ACIDS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | POLYUNSATURATED FATTY ACIDS |
graph TD
POLYUNSATURATED_FATTY_ACIDS[POLYUNSATURATED FATTY ACIDS]
POLYUNSATURATED_FATTY_ACIDS -->|component_of| Bis_monoacylglycero_phosphate[Bis(monoacylglycero)phosphate]
POLYUNSATURATED_FATTY_ACIDS -->|contributes to| Ferroptosis[Ferroptosis]
POLYUNSATURATED_FATTY_ACIDS -.protects against.-> Neurodegeneration[Neurodegeneration]
POLYUNSATURATED_FATTY_ACIDS -->|modulates| Mitochondrial_function[Mitochondrial function]
POLYUNSATURATED_FATTY_ACIDS -->|modulates| Lipid_Metabolism[Lipid Metabolism]
POLYUNSATURATED_FATTY_ACIDS -->|modulates| INFLAMMATION[INFLAMMATION]
POLYUNSATURATED_FATTY_ACIDS -->|protective_against| amyotrophic_lateral_sclerosis[amyotrophic lateral sclerosis]
POLYUNSATURATED_FATTY_ACIDS -->|protective_against| frontotemporal_dementia[frontotemporal dementia]
POLYUNSATURATED_FATTY_ACIDS -->|treats| autolysosomal_dysfunction[autolysosomal dysfunction]
POLYUNSATURATED_FATTY_ACIDS -.protects against.-> Alzheimer_s_Disease[Alzheimer's Disease]
Lysophosphatidylcholines[Lysophosphatidylcholines] -->|transports| POLYUNSATURATED_FATTY_ACIDS
ALOX12[ALOX12] -->|interacts| POLYUNSATURATED_FATTY_ACIDS
APOE[APOE] -->|inhibits| POLYUNSATURATED_FATTY_ACIDS
ApoE[ApoE] -->|inhibits| POLYUNSATURATED_FATTY_ACIDS| Target | Relation | Type | Str |
|---|---|---|---|
| Ferroptosis | contributes_to | process | 0.85 |
| Bis(monoacylglycero)phosphate | component_of | compound | 0.85 |
| Neurodegeneration | protects_against | process | 0.85 |
| amyotrophic lateral sclerosis | protective_against | disease | 0.80 |
| frontotemporal dementia | protective_against | disease | 0.80 |
| Multiple Sclerosis | associated_with | disease | 0.80 |
| Lipid Metabolism | modulates | pathway | 0.80 |
| INFLAMMATION | modulates | process | 0.80 |
| Mitochondrial function | modulates | process | 0.80 |
| Brain | associated_with | brain_region | 0.78 |
| autolysosomal dysfunction | treats | process | 0.75 |
| Alzheimer's Disease | protects_against | disease | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALOX15 | associated_with | gene | 0.95 |
| Lysophosphatidylcholines | transports | compound | 0.90 |
| ALOX12 | interacts_with | gene | 0.85 |
| Lysophosphatidylcholines | mediates | compound | 0.82 |
| ApoE | inhibits | protein | 0.80 |
| APOE | inhibits | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning POLYUNSATURATED FATTY ACIDS in their description or question text
No additional research found