gene

PRDX2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRDX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

6Outgoing

8Incoming

0Experiments

0Debates

Summary

PRDX2 is a typical 2-Cys peroxiredoxin that reduces hydrogen peroxide, peroxynitrite, and organic hydroperoxides. It functions as both a peroxidase and molecular chaperone, providing critical neuroprotection in Parkinson's disease, Alzheimer's disease, and other neurodegenerative conditions.

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🧬 Gene Info

Gene Symbol	PRDX2
Full Name	Peroxiredoxin 2
Chromosome	19p13.13
Protein Type	Enzyme
Function	is a critical antioxidant enzyme in the neurobiology of neurodegenerative diseases.
Primary Expression	Erythrocytes, Brain, Liver, Kidney, Heart
Molecular Weight	22 kDa
Amino Acids	198 aa
UniProt ID	P32189
NCBI Gene ID	7003
Ensembl ID	ENSG00000167612
OMIM	607386
GeneCards	PRDX2
Human Protein Atlas	PRDX2
N-terminal region	Contains the first conserved cysteine (Cys⁵¹)
Associated Diseases	Parkinson's disease, Alzheimer's disease
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PRDX2 — AlphaFold P32189 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PRDX2 — Peroxiredoxin 2

gene · 3179 words

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PRDX2 (Peroxiredoxin 2)

protein · 1431 words

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Pathway Diagram

graph TD
    PRDX2["PRDX2"]
    TREM2["TREM2"]
    PRDX2 -->|"upregulates"| TREM2
    Als{"Als"}
    PRDX2 -->|"expressed in"| Als
    Ms{"Ms"}
    PRDX2 -->|"expressed in"| Ms
    PIK3C3["PIK3C3"]
    PRDX2 -->|"associated with"| PIK3C3
    neurodegeneration["neurodegeneration"]
    PRDX2 -->|"implicated in"| neurodegeneration
    OxPC["OxPC"]
    OxPC -->|"activates"| PRDX2
    microglia["microglia"]
    microglia -->|"upregulates"| PRDX2
    NR3C1["NR3C1"]
    NR3C1 -->|"associated with"| PRDX2
    TXN["TXN"]
    TXN -->|"associated with"| PRDX2
    AP2B1["AP2B1"]
    AP2B1 -->|"associated with"| PRDX2
    GRB2["GRB2"]
    GRB2 -->|"associated with"| PRDX2
    style PRDX2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PRDX2	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
TREM2	upregulates	protein	0.80
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
PIK3C3	associated_with	gene	0.60

Incoming (8)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PRDX2	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
OxPC	activates	chemical	0.80
microglia	upregulates	cell_type	0.70
NR3C1	associated_with	gene	0.60
TXN	associated_with	gene	0.60
AP2B1	associated_with	gene	0.60
GRB2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRDX2 in their description or question text

No additional research found