gene

PPP1R1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP1R1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

6Outgoing

2Incoming

0Experiments

0Debates

Summary

Page for PPP1R1B Gene

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🧬 Gene Info

Gene Symbol	PPP1R1B
Full Name	Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B
Chromosome	17q21.31
Protein Type	Phosphatase
Function	DARPP-32 is a bifunctional signaling protein that acts as both a protein phosphatase 1 (PP1) inhibitor and a protein kinase A (PKA) substrate.
Primary Expression	the striatum (caudate nucleus and putamen), with highest levels in medium spiny neurons
Subcellular Localization	nucleus accumbens, olfactory tubercle, and cerebral cortex
Molecular Weight	32 kDa
Pathways	Synaptic Plasticity
UniProt ID	Q9UDW6
NCBI Gene ID	5500
Ensembl ID	ENSG00000131759
OMIM	168600
GeneCards	PPP1R1B
Human Protein Atlas	PPP1R1B
Associated Diseases	neurodegeneration
KG Connections	8 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PPP1R1B — AlphaFold Q9UDW6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PPP1R1B Gene

gene · 639 words

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Pathway Diagram

graph TD
    PPP1R1B["PPP1R1B"]
    Als{"Als"}
    PPP1R1B -->|"expressed in"| Als
    Schizophrenia{"Schizophrenia"}
    PPP1R1B -->|"expressed in"| Schizophrenia
    SNAP29["SNAP29"]
    PPP1R1B -->|"expressed in"| SNAP29
    CDK5["CDK5"]
    PPP1R1B -->|"regulates"| CDK5
    Synaptic_Plasticity(["Synaptic Plasticity"])
    PPP1R1B -->|"regulates"| Synaptic_Plasticity
    Immune_Response(["Immune Response"])
    PPP1R1B -->|"expressed in"| Immune_Response
    neurodegeneration["neurodegeneration"]
    PPP1R1B -->|"implicated in"| neurodegeneration
    GSN["GSN"]
    GSN -->|"regulates"| PPP1R1B
    SNAP25["SNAP25"]
    SNAP25 -->|"expressed in"| PPP1R1B
    style PPP1R1B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Als	expressed_in	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Synaptic Plasticity	regulates	pathway	0.60
Immune Response	expressed_in	pathway	0.60
SNAP29	expressed_in	gene	0.60
CDK5	regulates	gene	0.60

Incoming (2)

Source	Relation	Type	Str
GSN	regulates	gene	0.60
SNAP25	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPP1R1B in their description or question text

No additional research found