concept

PI3K-AKT SIGNALING PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K-AKT SIGNALING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

17Outgoing

16Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PI3K-AKT SIGNALING PATHWAY

Pathway Diagram

graph TD
    PI3K_AKT_SIGNALING_PATHWAY["PI3K-AKT SIGNALING PATHWAY"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"upstream_of"| platelet_activation["platelet activation"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"promotes"| lipid_deposition["lipid deposition"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"promotes"| inflammation["inflammation"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"regulates"| solar_dermatitis["solar dermatitis"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"modulates"| Neuronal_Apoptosis["Neuronal Apoptosis"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"promotes"| atherosclerosis["atherosclerosis"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"regulates"| TNF__["TNF-alpha"]
    Fusobacterium_nucleatum["Fusobacterium nucleatum"] -->|"activates"| PI3K_AKT_SIGNALING_PATHWAY
    AKT["AKT"] -->|"downstream_of"| PI3K_AKT_SIGNALING_PATHWAY
    Gbp_protein["Gbp protein"] -->|"activates"| PI3K_AKT_SIGNALING_PATHWAY
    Andrographis_paniculata["Andrographis paniculata"] -->|"modulates"| PI3K_AKT_SIGNALING_PATHWAY
    Yiqi_Tongluo_Granule["Yiqi Tongluo Granule"] -->|"activates"| PI3K_AKT_SIGNALING_PATHWAY
    QHZYF["QHZYF"] -->|"regulates"| PI3K_AKT_SIGNALING_PATHWAY
    DOTP["DOTP"] -->|"modulates"| PI3K_AKT_SIGNALING_PATHWAY

Outgoing (17)

Target	Relation	Type	Str
lipid deposition	promotes	process	0.90
platelet activation	upstream_of	process	0.90
solar dermatitis	associated_with	disease	0.90
inflammation	promotes	process	0.90
solar dermatitis	regulates	disease	0.88
inflammation	regulates	process	0.87
Pre-Regenerative Niche Formation	activates	process	0.85
IL6	regulates	protein	0.85
atherosclerosis	promotes	disease	0.85
TNF-α	regulates	protein	0.85
Neuronal Apoptosis	modulates	process	0.85
inflammation	regulates	process	0.82
ovarian cancer	associated_with	disease	0.80
IL-6	upstream_of	protein	0.80
Cerebral Ischemia/Reperfusion Injury	protects_against	disease	0.80
coronary microembolism	promotes	disease	0.80
chronic spontaneous urticaria	associated_with	disease	0.80

Incoming (16)

Source	Relation	Type	Str
Fusobacterium nucleatum	activates	pathogen	0.95
AKT	downstream_of	gene	0.90
Gbp protein	activates	protein	0.88
Andrographis paniculata	modulates	drug	0.88
MTOR	downstream_of	protein	0.85
Yiqi Tongluo Granule	activates	drug	0.85
QHZYF	regulates	drug	0.85
DOTP	modulates	drug	0.85
QHZYF	regulates	drug	0.85
UV exposure	activates	process	0.82
EGFR	upstream_of	protein	0.80
MYC	downstream_of	gene	0.80
PFOA	modulates	drug	0.75
TNF	upstream_of	protein	0.75
DOTP	modulates	drug	0.75
TNF-α	upstream_of	protein	0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PI3K-AKT SIGNALING PATHWAY in their description or question text

No additional research found