Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PI3K-AKT-MTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Name | PI3K-AKT-MTOR |
| Key Genes/Proteins | AMPK |
| Related Diseases | Cancer, CASTRATION-RESISTANT PROSTATE CANCER, PROSTATE CANCER |
graph TD
PI3K_AKT_MTOR["PI3K-AKT-MTOR"]
PI3K_AKT_MTOR -->|"involved_in"| Prostate_Cancer["Prostate Cancer"]
PI3K_AKT_MTOR -->|"contributes to"| Castration_Resistant_Prostate_["Castration-Resistant Prostate Cancer"]
PI3K_AKT_MTOR -->|"causes"| Ferroptosis_Resistance["Ferroptosis Resistance"]
PI3K_AKT_MTOR -->|"mediates"| Androgen_Deprivation_Therapy_R["Androgen Deprivation Therapy Resistance"]
PI3K_AKT_MTOR -->|"activates"| Cell_Proliferation["Cell Proliferation"]
PI3K_AKT_MTOR -->|"activates"| Cell_Survival["Cell Survival"]
PI3K_AKT_MTOR -->|"regulates"| Protein_Synthesis["Protein Synthesis"]
PI3K_AKT_MTOR -->|"involved_in"| Neurodegeneration["Neurodegeneration"]
SEMA3F["SEMA3F"] -->|"inhibits"| PI3K_AKT_MTOR
RPL36["RPL36"] -->|"inhibits"| PI3K_AKT_MTOR
IGF_1["IGF-1"] -->|"activates"| PI3K_AKT_MTOR| Target | Relation | Type | Str |
|---|---|---|---|
| Ferroptosis Resistance | causes | phenotype | 0.95 |
| Castration-Resistant Prostate Cancer | contributes_to | disease | 0.95 |
| Prostate Cancer | involved_in | disease | 0.95 |
| PROSTATE CANCER | promotes | disease | 0.90 |
| CASTRATION-RESISTANT PROSTATE CANCER | promotes | disease | 0.90 |
| Androgen Deprivation Therapy Resistance | mediates | phenotype | 0.90 |
| Cell Proliferation | activates | process | 0.90 |
| Cell Survival | activates | process | 0.90 |
| Protein Synthesis | regulates | process | 0.90 |
| Cancer | involved_in | disease | 0.90 |
| prostate cancer progression | implicated_in | disease | 0.90 |
| Autophagy | modulates | process | 0.85 |
| Autophagy-Apoptosis Balance | regulates | process | 0.85 |
| AR | interacts_with | receptor | 0.85 |
| Oxidative Stress | protects_against | process | 0.85 |
| Autophagy | regulates | process | 0.85 |
| Neurodegeneration | involved_in | disease | 0.85 |
| aging | promotes | phenotype | 0.80 |
| Alzheimer's disease | activates | disease | 0.70 |
| insulin signalling | interacts_with | pathway | 0.70 |
| insulin signaling | interacts_with | pathway | 0.70 |
| Down syndrome | activates | disease | 0.70 |
| early-onset Alzheimer's disease | activates | disease | 0.70 |
| neurodegenerative diseases | associated_with | disease | 0.70 |
| Alzheimer's disease | associated_with | disease | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR | 0.718 | Alzheimer's disease | TREM2 agonism vs antagonism in DAM micro |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Single-cell RNA sequencing of microglial states in AD hippocampus | exploratory | Alzheimer's disease | 0.850 | 0.00 | AD mouse hippocampus | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PI3K-AKT-MTOR in their description or question text
No additional research found