Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PDPK1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Pdpk1 Protein is involved in cellular processes relevant to neurodegeneration. For detailed information, refer to the References section.
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| Gene Symbol | PDPK1PROTEIN |
| Full Name | 3-Phosphoinositide Dependent Kinase 1 |
| Protein Type | Protein |
| Function | is a serine/threonine kinase that activates AKT and other AGC kinases. |
| Primary Expression | cancers and promotes cell survival and proliferation |
| Subcellular Localization | ** Cytoplasm, Plasma Membrane * **Protein Family:** AGC kinase family (3-phospho |
| Molecular Weight | 63 kDa |
| UniProt ID | Search UniProt |
| GeneCards | PDPK1PROTEIN |
| Human Protein Atlas | PDPK1PROTEIN |
| Protein Kinase B (Akt) | primary PDK1 substrate and central survival kinase |
| Phosphoinositide 3-Kinase (PI3K) | upstream activator |
| Associated Diseases | Infection |
| Interactions | AKT, AKT1, CANCER, DNA, EGFR, EIF4EBP1 |
| KG Connections | 68 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PDPK1PROTEIN["PDPK1PROTEIN"]
neurodegeneration["neurodegeneration"]
PDPK1PROTEIN -->|"implicated_in"| neurodegeneration
style PDPK1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| proteins-pdpk1-protein | describes | wiki | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PDPK1PROTEIN in their description or question text
No additional research found