Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PDE4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Source | Relation | Type | Str |
|---|---|---|---|
| Apremilast | inhibits | drug | 0.95 |
| Caffeine | inhibits | compound | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| PDE4 Inhibition as Inflammatory Reset for PD Oligodendrocyte | 0.749 | neuroinflammation | How do oligodendrocytes initiate neuroin |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Molecular docking analysis of aminophylline binding targets | exploratory | depression | 0.800 | 0.00 | in silico molecular docking | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PDE4 in their description or question text
No additional research found