| Gene Symbol | PDE4A |
| Full Name | Phosphodiesterase 4A |
| Function | PDE4A encodes a cAMP-specific phosphodiesterase belonging to the PDE4 family |
| UniProt ID | P27815 |
| Ensembl ID | ENSG00000065989 |
| GeneCards | PDE4A |
| Human Protein Atlas | PDE4A |
| cAMP → AMP | Catalyzes the breakdown of cAMP toAMP |
| cAMP-specific | Does not hydrolyze cGMP |
| Isoforms | Multiple splice variants (PDE4A1-11) with different N-termini |
| Phosphorylation | PKA phosphorylation can regulate activity |
| Protein interactions | Binds to various scaffolding proteins |
| Compartmentalization | Targeted to specific cellular compartments |
| High expression | Cerebral cortex, hippocampus, olfactory bulb, cerebellum |
| Moderate expression | Lung, immune cells, heart |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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