| Gene Symbol | PDE4B |
| Full Name | Phosphodiesterase 4B (cAMP-specific phosphodiesterase) |
| Aliases | PDE4BPROTEIN |
| Chromosome | 1p31.3 |
| Protein Type | Enzyme |
| Function | is a member of the phosphodiesterase 4 family that specifically hydrolyzes cyclic AMP (cAMP), terminating cAMP-mediated signaling. |
| Primary Expression | brain - PDE4B2: 664 amino acids, the most abundant isoform in immune cells - PDE4B3: 726 amino acids, enriched in testis and brain - PDE4B4 |
| Subcellular Localization | </strong></td><td>Cytoplasm, membrane-associated</td></tr> |
| Amino Acids | 721 aa |
| Exons | 16 |
| Pathways | Mitophagy, Oxidative Stress, neuronal apoptosis |
| UniProt ID | [Q07343](https://www.uniprot.org/uniprot/Q07343) |
| Ensembl ID | ENSG00000104288 |
| OMIM | 610172 |
| GeneCards | PDE4B |
| Human Protein Atlas | PDE4B |
| Associated Diseases | Als, Alzheimer, dementia |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, APP, APP/PS1, BCL-2 |
| KG Connections | 93 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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