gene 4,037 words KG: NPAS3
Contents

NPAS3 Gene

🧬 Gene Info
Gene SymbolNPAS3
Full NameNeuronal PAS Domain Protein 3
Chromosome12q23.3
Protein TypeTranscription Factor
Functionencodes a brain-specific transcription factor belonging to the bHLH-PAS (basic Helix-Loop-Helix-Per-Arnt-Sim) family of transcriptional regulators.
Primary ExpressionBrain-specific (neurons)
Molecular Weight65 kDa
Amino Acids593 aa
Exons27
UniProt ID[Q8TDW5](https://www.uniprot.org/uniprot/Q8TDW5)
Ensembl IDENSG00000173137
GeneCardsNPAS3
Human Protein AtlasNPAS3
Associated DiseasesAlzheimer's Disease, Intellectual Disability, Parkinson's Disease, Pulmonary Hypoplasia, Schizophrenia
KG Connections9 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (12)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
CYP46A1 Overexpression Gene Therapy
Score: 0.95
Circadian Clock-Autophagy Synchronization
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (4)

Neurodegeneration
disease · KG edge: implicated_in
ARNT - Aryl Hydrocarbon Receptor Nuclear Translocator
gene · KG edge: binds
txnip
gene · KG edge: regulates
VGF — VGF Nerve Growth Factor Inducible
gene · KG edge: regulates

Knowledge Graph (9 edges)

NPAS3 associated_with Intellectual Disability
NPAS3 binds ARNT
NPAS3 regulates VGF
NPAS3 regulates TXNIP
NPAS3 causes Pulmonary Hypoplasia
NPAS3 downregulates Congenital Diaphragmatic Hernia
NPAS3 associated_with Schizophrenia
NPAS3 associated_with Alzheimer's Disease
NPAS3 associated_with Parkinson's Disease

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