protein 3,677 words KG: PRION_PROTEIN
Contents

Prion Protein (PRNP)

🔬 Protein Info
Gene SymbolPRNP
AliasesPRION_PROTEIN
Chromosome20p13
Protein FamilyPrion protein family
Functionis a GPI-anchored glycoprotein expressed predominantly in the central nervous system.
Primary ExpressionCell membrane ( GPI-anchored), cytoplasm, nucleus
Subcellular LocalizationCell membrane ( GPI-anchored), cytoplasm, nucleus
Molecular Weight33-35 kDa (253 amino acids)
Amino Acids253 aa
UniProt IDP04156
GeneCardsPRNP
Human Protein AtlasPRNP
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (30)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Circadian Clock-Autophagy Synchronization
Score: 0.76
PARP1 Inhibition Therapy
Score: 0.74
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73

Related Analyses (16)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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