Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NEUROVASCULAR UNIT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | NEUROVASCULAR UNIT |
| Related Diseases | BRAIN DISORDERS |
Knowledge base pages for this entity
graph TD
NEUROVASCULAR_UNIT["NEUROVASCULAR UNIT"]
NEUROVASCULAR_UNIT -->|"component_of"| Blood_Brain_Barrier["Blood-Brain Barrier"]
NEUROVASCULAR_UNIT -->|"contributes to"| Neuroinflammation["Neuroinflammation"]
Neurons["Neurons"] -->|"component_of"| NEUROVASCULAR_UNIT
Endothelial_Cells["Endothelial Cells"] -->|"component_of"| NEUROVASCULAR_UNIT
Pericytes["Pericytes"] -->|"component_of"| NEUROVASCULAR_UNIT
Vascular_Smooth_Muscle_Cells["Vascular Smooth Muscle Cells"] -->|"component_of"| NEUROVASCULAR_UNIT
Glial_Cells["Glial Cells"] -->|"component_of"| NEUROVASCULAR_UNIT
Extracellular_Matrix["Extracellular Matrix"] -->|"component_of"| NEUROVASCULAR_UNIT
AMPK["AMPK"] -->|"regulates"| NEUROVASCULAR_UNIT| Target | Relation | Type | Str |
|---|---|---|---|
| Blood-Brain Barrier | component_of | process | 0.95 |
| Neuroinflammation | associated_with | process | 0.95 |
| Blood-Brain Barrier | regulates | process | 0.90 |
| neurological diseases | associated_with | disease | 0.80 |
| neuroinflammation | interacts_with | process | 0.70 |
| neuroinflammation | mediates | process | 0.70 |
| BRAIN DISORDERS | implicated_in | disease | 0.70 |
| neurodegeneration | interacts_with | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Astrocytes | involved_in | cell_type | 0.95 |
| Neurons | component_of | cell_type | 0.95 |
| Endothelial Cells | component_of | cell_type | 0.95 |
| Pericytes | component_of | cell_type | 0.95 |
| Vascular Smooth Muscle Cells | component_of | cell_type | 0.95 |
| Glial Cells | component_of | cell_type | 0.95 |
| specialized microvascular endothelial cells | associated_with | cell_type | 0.95 |
| glial cell activation | modulates | process | 0.90 |
| 28515434 | regulates | paper | 0.90 |
| 28515434 | is composed of | paper | 0.90 |
| Extracellular Matrix | component_of | process | 0.90 |
| KCNK2 | involved_in | gene | 0.85 |
| Pericytes | involved_in | cell_type | 0.82 |
| LRP-1 | expressed_in | gene | 0.80 |
| PDGFB | modulates | gene | 0.80 |
| PDGFRB | modulates | gene | 0.80 |
| AMPK | regulates | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| N-acetylcysteine (NAC) / System Xc⁻ - Mediated GSH Support f | 0.760 | neurodegeneration | Can ferroptosis inhibitors prevent BBB d |
| P2RY12-driven autophagy impairment in cerebral VSMCs mediate | 0.585 | neurodegeneration | How does P2RY12-mediated VSMC dysfunctio |
| Neurovascular Unit SPI1 Signaling Hub | 0.455 | neuroinflammation | How does SPI1 transcriptionally regulate |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NEUROVASCULAR UNIT in their description or question text
No additional research found