gene

MIEF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MIEF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

10Outgoing

5Incoming

0Experiments

0Debates

Summary

MIEF1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Als, Cancer, Ms. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MIEF1
Chromosome	17q11.2
Function	MIEF1 localizes to the mitochondrial outer membrane where it recruits Drp1 from the cytosol to the mitochondrial surface, initiating the fission process.
Primary Expression	Ubiquitous, highest in brain, heart, and muscle
Amino Acids	463 aa
Pathways	Complement
UniProt ID	Q9H0X6
NCBI Gene ID	54443
Ensembl ID	ENSG00000135269
GeneCards	MIEF1
Human Protein Atlas	MIEF1
Associated Diseases	neurodegeneration
Interactions	CANCER, DRP1, NRF2, OXIDATIVE STRESS
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MIEF1 — AlphaFold Q9H0X6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

mief1

gene · 1927 words

→

Pathway Diagram

graph TD
    MIEF1["MIEF1"]
    Cancer{"Cancer"}
    MIEF1 -->|"activates"| Cancer
    Als{"Als"}
    MIEF1 -->|"regulates"| Als
    Ms{"Ms"}
    MIEF1 -->|"regulates"| Ms
    NRF2["NRF2"]
    MIEF1 -->|"activates"| NRF2
    DRP1["DRP1"]
    MIEF1 -->|"activates"| DRP1
    Oxidative_Stress(["Oxidative Stress"])
    MIEF1 -->|"activates"| Oxidative_Stress
    TAZ["TAZ"]
    MIEF1 -->|"regulates"| TAZ
    Complement(["Complement"])
    MIEF1 -->|"regulates"| Complement
    CANCER["CANCER"]
    MIEF1 -->|"activates"| CANCER
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    MIEF1 -->|"activates"| OXIDATIVE_STRESS
    neurodegeneration["neurodegeneration"]
    MIEF1 -->|"implicated in"| neurodegeneration
    SREBP1["SREBP1"]
    SREBP1 -->|"regulates"| MIEF1
    DRP1 -->|"regulates"| MIEF1
    YAP["YAP"]
    YAP -->|"regulates"| MIEF1
    NRF2 -->|"regulates"| MIEF1
    DRP1 -->|"activates"| MIEF1
    style MIEF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
Cancer	activates	disease	0.65
OXIDATIVE STRESS	activates	gene	0.60
Complement	regulates	pathway	0.60
Oxidative Stress	activates	pathway	0.60
CANCER	activates	gene	0.60
NRF2	activates	gene	0.60
DRP1	activates	gene	0.60
TAZ	regulates	gene	0.60

Incoming (5)

Source	Relation	Type	Str
SREBP1	regulates	gene	0.60
YAP	regulates	gene	0.60
DRP1	regulates	gene	0.60
NRF2	regulates	gene	0.60
DRP1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MIEF1 in their description or question text

No additional research found