gene

LIMK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LIMK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

0Analyses

11Outgoing

1Incoming

0Experiments

0Debates

Summary

LIMK2 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, biomarker for, implicated in. Associated with Als. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	LIMK2
Chromosome	22q12.2
Protein Type	Serine/Threonine Kinase
Function	Cofilin Phosphorylation: LIMK2 phosphorylates cofilin-1 (non-muscle cofilin) and cofilin-2 (muscle cofilin) at Ser3, inhibiting their actin-binding and depolymerizing activity [@mori1999].
Primary Expression	various tissues, with particularly high expression in the brain, where it contributes to neuronal development, synaptic plasticity, and cytoskeletal o
Subcellular Localization	</div> [@ferrari2013]
Molecular Weight	72 kDa
GeneCards	LIMK2
Human Protein Atlas	LIMK2
PDZ Domain	A postsynaptic density protein (PSD-95)/Disc large/Zonula occludens-1 (PDZ) domain that scaffolds signaling complexes and facilitates interactions with membrane-associated proteins.
Kinase Domain (C-terminal)	The catalytic serine/threonine kinase domain that phosphorylates cofilin and other substrates. This domain shares high homology with LIMK1 but has distinct regulatory properties [@ikebe1999].
Associated Diseases	neurodegeneration
KG Connections	12 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LIM Kinase 2 (LIMK2)

protein · 1333 words

→

LIMK2 Gene

gene · 631 words

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Pathway Diagram

graph TD
    LIMK2["LIMK2"]
    Als{"Als"}
    LIMK2 -->|"biomarker_for"| Als
    RAS(["RAS"])
    LIMK2 -->|"expressed_in"| RAS
    GENES(["GENES"])
    LIMK2 -->|"biomarker_for"| GENES
    AKT(["AKT"])
    LIMK2 -->|"expressed_in"| AKT
    OVERVIEW(["OVERVIEW"])
    LIMK2 -->|"biomarker_for"| OVERVIEW
    MTOR(["MTOR"])
    LIMK2 -->|"expressed_in"| MTOR
    PI3K(["PI3K"])
    PI3K -->|"expressed_in"| LIMK2
    style LIMK2 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (11)

Target	Relation	Type	Str
Als	biomarker_for	disease	0.65
GENES	biomarker_for	gene	0.60
Pi3K/Akt	expressed_in	pathway	0.60
Differentiation	biomarker_for	pathway	0.60
Mtor	expressed_in	pathway	0.60
Cell Division	biomarker_for	pathway	0.60
RAS	expressed_in	gene	0.60
Mapk	expressed_in	pathway	0.60
AKT	expressed_in	gene	0.60
OVERVIEW	biomarker_for	gene	0.60
MTOR	expressed_in	gene	0.60

Incoming (1)

Source	Relation	Type	Str
PI3K	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LIMK2 in their description or question text

No additional research found