| Gene Symbol | LIMK2 |
| Chromosome | 22q12.2 |
| Protein Type | Serine/Threonine Kinase |
| Function | Cofilin Phosphorylation: LIMK2 phosphorylates cofilin-1 (non-muscle cofilin) and cofilin-2 (muscle cofilin) at Ser3, inhibiting their actin-binding and depolymerizing activity [@mori1999]. |
| Primary Expression | various tissues, with particularly high expression in the brain, where it contributes to neuronal development, synaptic plasticity, and cytoskeletal o |
| Subcellular Localization | </div> [@ferrari2013] |
| Molecular Weight | 72 kDa |
| GeneCards | LIMK2 |
| Human Protein Atlas | LIMK2 |
| PDZ Domain | A postsynaptic density protein (PSD-95)/Disc large/Zonula occludens-1 (PDZ) domain that scaffolds signaling complexes and facilitates interactions with membrane-associated proteins. |
| Kinase Domain (C-terminal) | The catalytic serine/threonine kinase domain that phosphorylates cofilin and other substrates. This domain shares high homology with LIMK1 but has distinct regulatory properties [@ikebe1999]. |
| Associated Diseases | neurodegeneration |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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