gene

KLK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KLK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

11Outgoing

7Incoming

0Experiments

0Debates

Summary

KLK1 encodes kallikrein-related peptidase 1, a serine protease involved in kinin generation, inflammation, and tissue remodeling in neurodegeneration

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🧬 Gene Info

Gene Symbol	KLK1
Chromosome	19q13.33
Protein Family	Kallikrein (Serine protease) family
Protein Type	Protease
Function	is a member of the kallikrein family of serine proteases, primarily known for its roles in the kinin system, blood pressure regulation, and inflammation.
Primary Expression	Kidney, pancreas, brain, salivary glands
Subcellular Localization	Secreted (extracellular)
Molecular Weight	29 kDa
Amino Acids	262 aa
Pathways	NF-κB, MAPK pathway
UniProt ID	P06858
NCBI Gene ID	3756
Ensembl ID	ENSG00000167748
GeneCards	KLK1
Human Protein Atlas	KLK1
Associated Diseases	neurodegeneration
Interactions	ABCC8, KLF2, PAH
KG Connections	18 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KLK1 — AlphaFold P06858 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KLK1 Gene

gene · 1041 words

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KLK1 Protein

protein · 504 words

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Pathway Diagram

graph TD
    KLK1["KLK1"]
    Als{"Als"}
    KLK1 -->|"therapeutic_target"| Als
    Neuroinflammation{"Neuroinflammation"}
    KLK1 -->|"therapeutic_target"| Neuroinflammation
    Stroke{"Stroke"}
    KLK1 -->|"therapeutic_target"| Stroke
    Atherosclerosis{"Atherosclerosis"}
    KLK1 -->|"therapeutic_target"| Atherosclerosis
    Inflammation{"Inflammation"}
    KLK1 -->|"therapeutic_target"| Inflammation
    STROKE(["STROKE"])
    KLK1 -->|"therapeutic_target"| STROKE
    OXIDATIVE_STRESS(["OXIDATIVE STRESS"])
    OXIDATIVE_STRESS -->|"therapeutic_target"| KLK1
    AND(["AND"])
    AND -->|"therapeutic_target"| KLK1
    MET(["MET"])
    MET -->|"therapeutic_target"| KLK1
    style KLK1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (11)

Target	Relation	Type	Str
Stroke	therapeutic_target	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
MET	therapeutic_target	gene	0.60
Stem Cell	therapeutic_target	pathway	0.60
PAH	interacts_with	gene	0.60
STROKE	therapeutic_target	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
Oxidative Stress	therapeutic_target	pathway	0.60

Incoming (7)

Source	Relation	Type	Str
KLF2	associated_with	gene	0.60
KLF2	interacts_with	gene	0.60
ABCC8	interacts_with	gene	0.60
STROKE	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KLK1 in their description or question text

No additional research found