protein

HTR2APROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTR2APROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Htr2A Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	HTR2APROTEIN
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	** \| Plasma membrane, dendritic shafts, postsynaptic densities \|
Molecular Weight	60 kDa
GeneCards	HTR2APROTEIN
Human Protein Atlas	HTR2APROTEIN
Long C-terminal tail	Contains serine/threonine residues for phosphorylation and desensitization
Differential splicing	Generates multiple isoforms with distinct coupling properties
Palmitoylation sites	In the C-tail for membrane anchoring
Phospholipase C activation	Increases IP3 and DAG, raising intracellular calcium
Pyramidal neuron modulation	Excitatory effects in prefrontal cortex
Platelet aggregation	Peripheral 5-HT2A mediates platelet shape change
Smooth muscle contraction	Vascular and gastrointestinal effects
Dreaming and consciousness	HTR2A activity correlates with REM sleep
Associated Diseases	Als, Alzheimer, Autism, Bipolar, Cancer
Interactions	CACNA1B, CACNA1H, DRD1, DRD2, GABRA1, GABRB2
KG Connections	155 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

htr2a Protein

protein · 586 words

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Pathway Diagram

graph TD
    HTR2APROTEIN["HTR2APROTEIN"]
    neurodegeneration["neurodegeneration"]
    HTR2APROTEIN -->|"implicated_in"| neurodegeneration
    style HTR2APROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HTR2APROTEIN in their description or question text

No additional research found