protein

HSP40PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSP40PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

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Summary

Hsp40 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	HSP40PROTEIN
Protein Type	Chaperone
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	80 kDa
Amino Acids	70 aa
GeneCards	HSP40PROTEIN
Human Protein Atlas	HSP40PROTEIN
J-domain	~70 amino acids, mediates interaction with Hsp70
G/F-rich region	Glycine-phenylalanine rich flexible linker
C-terminal substrate-binding domain	Variable, determines specificity
Alzheimer's disease	DNAJC family members reduce Aβ aggregation
Parkinson's disease	DNAJC proteins prevent alpha-synuclein aggregation
ALS	Modulate mutant SOD1 and FUS aggregation
Huntington's disease	DNAJC proteins assist mutant huntingtin clearance
Associated Diseases	ALS, dementia, disease, frontotemporal, neurodegeneration, Neurodegenerative Diseases
Interactions	AMYLOID, APOE4, ATP, BAG1, DNAJA1, DNAJB1
KG Connections	46 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Hsp40 Protein

protein · 874 words

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Pathway Diagram

graph TD
    HSP40PROTEIN["HSP40PROTEIN"]
    neurodegeneration["neurodegeneration"]
    HSP40PROTEIN -->|"implicated_in"| neurodegeneration
    style HSP40PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HSP40PROTEIN in their description or question text

No additional research found