gene

HNNRPK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HNNRPK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

1Outgoing

0Incoming

0Experiments

0Debates

Summary

HNRNPK — Heterogeneous Nuclear Ribonucleoprotein K

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🧬 Gene Info

Gene Symbol	HNRNPK
Full Name	Heterogeneous Nuclear Ribonucleoprotein K
Chromosome	9q21.32
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	stress granules and is involved in RNA granule dynamics, which are critical for cellular stress responses and are dysreg
Molecular Weight	51 kDa
Exons	17
Pathways	MAPK signaling, Wnt signaling
Ensembl ID	ENSG00000165119
GeneCards	HNRNPK
Human Protein Atlas	HNRNPK
Full-length isoform (463 aa)	Contains all three KH domains
Splice variants	Produce isoforms with distinct subcellular localizations
Associated Diseases	Als
Interactions	AND, ATG, AUTOPHAGY, CALCOCO2, CKB, EGR1
KG Connections	74 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: HNNRPK — AlphaFold P61956 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HNRNPK — Heterogeneous Nuclear Ribonucleoprotein K

gene · 816 words

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Pathway Diagram

graph TD
    HNRNPK["HNRNPK Gene"]
    HNRNPK_PROT["hnRNP K Protein"]
    TRANSCRIPTION["Transcriptional Regulation"]
    RNA_PROCESSING["RNA Processing and Splicing"]
    RNA_TRANSPORT["RNA Transport"]
    TRANSLATION["Translation Control"]
    PKC_SIGNALING["PKC Signaling"]
    DNA_DAMAGE["DNA Damage Response"]
    OXIDATIVE_STRESS["Oxidative Stress"]
    NEUROINFLAMMATION["Neuroinflammation"]
    PROTEIN_AGGREGATION["Protein Aggregation"]
    SYNAPTIC_DYSFUNCTION["Synaptic Dysfunction"]
    NEURONAL_DEATH["Neuronal Cell Death"]
    ALZHEIMERS["Alzheimer's Disease"]
    PARKINSONS["Parkinson's Disease"]
    ALS["Amyotrophic Lateral Sclerosis"]

    HNRNPK -->|"encodes"| HNRNPK_PROT
    HNRNPK_PROT -->|"regulates"| TRANSCRIPTION
    HNRNPK_PROT -->|"controls"| RNA_PROCESSING
    HNRNPK_PROT -->|"facilitates"| RNA_TRANSPORT
    HNRNPK_PROT -->|"modulates"| TRANSLATION
    PKC_SIGNALING -->|"phosphorylates"| HNRNPK_PROT
    DNA_DAMAGE -->|"activates"| HNRNPK_PROT
    OXIDATIVE_STRESS -->|"impairs"| HNRNPK_PROT
    HNRNPK_PROT -->|"dysfunction leads to"| PROTEIN_AGGREGATION
    PROTEIN_AGGREGATION -->|"triggers"| NEUROINFLAMMATION
    NEUROINFLAMMATION -->|"causes"| SYNAPTIC_DYSFUNCTION
    SYNAPTIC_DYSFUNCTION -->|"leads to"| NEURONAL_DEATH
    NEURONAL_DEATH -->|"manifests as"| ALZHEIMERS
    NEURONAL_DEATH -->|"manifests as"| PARKINSONS
    NEURONAL_DEATH -->|"manifests as"| ALS

    style HNRNPK fill:#1a3a4a,stroke:#4fc3f7
    style HNRNPK_PROT fill:#1a3a4a,stroke:#4fc3f7
    style TRANSCRIPTION fill:#2a1a3a,stroke:#ce93d8
    style RNA_PROCESSING fill:#2a1a3a,stroke:#ce93d8
    style PKC_SIGNALING fill:#1a3a2a,stroke:#81c784
    style DNA_DAMAGE fill:#3a1a1a,stroke:#ef5350
    style OXIDATIVE_STRESS fill:#3a1a1a,stroke:#ef5350
    style PROTEIN_AGGREGATION fill:#3a1a1a,stroke:#ef5350
    style NEUROINFLAMMATION fill:#3a1a1a,stroke:#ef5350
    style NEURONAL_DEATH fill:#3a1a1a,stroke:#ef5350
    style ALZHEIMERS fill:#3a2a1a,stroke:#ffa726
    style PARKINSONS fill:#3a2a1a,stroke:#ffa726
    style ALS fill:#3a2a1a,stroke:#ffa726

Outgoing (1)

Target	Relation	Type	Str
Cell Types	expressed_in	cell_type	0.80

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning HNNRPK in their description or question text

No additional research found