Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GLYCINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | GLYCINE |
graph TD
GLYCINE[GLYCINE]
GLYCINE -->|released_by| neurons[neurons]
GLYCINE -->|released_by| GABAergic_neurons[GABAergic neurons]
neurodegeneration[neurodegeneration] -->|disrupts| GLYCINE
PRMT1[PRMT1] -->|degrades| GLYCINE
neuroinflammation[neuroinflammation] -->|disrupts| GLYCINE
NMDA_receptor[NMDA receptor] -->|binds| GLYCINE
ALS[ALS] -->|activates| GLYCINE
frontotemporal_dementia[frontotemporal dementia] -->|disrupts| GLYCINE
ROS[ROS] -->|activates| GLYCINE| Target | Relation | Type | Str |
|---|---|---|---|
| neurons | released_by | cell_type | 0.70 |
| GABAergic neurons | released_by | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | disrupts | disease | 0.80 |
| PRMT1 | degrades | gene | 0.60 |
| PRMT1 | promotes | gene | 0.60 |
| neuroinflammation | disrupts | disease | 0.60 |
| NMDA receptor | binds | receptor | 0.60 |
| ATP | associated_with | gene | 0.60 |
| GABA | associated_with | gene | 0.60 |
| ROS | activates | gene | 0.60 |
| ROS | protects_against | gene | 0.60 |
| ROS | associated_with | gene | 0.60 |
| ALS | activates | gene | 0.60 |
| ALS | disrupts | disease | 0.60 |
| frontotemporal dementia | disrupts | disease | 0.60 |
| ALS | protects_against | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Glycine-Rich Domain Competitive Inhibition | 0.640 | neurodegeneration | TDP-43 phase separation therapeutics for |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| TDP-43 mutant mouse model cGAS/STING pathway analysis | validation | amyotrophic lateral sclerosis | 0.900 | 0.00 | TDP-43 mutant mice | proposed | N/A |
| TDP-43 mitochondrial invasion and DNA release via mPTP | exploratory | amyotrophic lateral sclerosis | 0.900 | 0.00 | cultured cells | proposed | N/A |
| TDP-43 mitochondrial invasion and mtDNA release in iPSC motor neurons | exploratory | Amyotrophic Lateral Sclerosis | 0.900 | 0.00 | iPSC-derived motor neurons | proposed | N/A |
| cGAS/STING pathway validation in TDP-43 mutant mice | validation | Amyotrophic Lateral Sclerosis | 0.850 | 0.00 | TDP-43 mutant mice | proposed | N/A |
| cGAMP biomarker analysis in ALS patient spinal cord samples | exploratory | Amyotrophic Lateral Sclerosis | 0.800 | 0.00 | Human ALS patient spinal cord | proposed | N/A |
| TDP-43 pathology prevalence and distribution in AD cases | exploratory | Alzheimer's disease | 0.800 | 0.00 | human postmortem brain tissue | proposed | N/A |
| Cognitive impact of TDP-43 pathology in AD patients | clinical | Alzheimer's disease | 0.700 | 0.00 | human patients | completed | N/A |
| Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| s:** - Single-cell RNA-seq to measure editing efficiency across differ | falsification | ALS | 0.400 | 0.50 | cell_line | proposed | $150,000 |
| ALS Progression Rate Heterogeneity — mechanism and biomarker predictor | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020] | Chua JP, De Calbiac H, Kabashi E, Barmad | Autophagy | 2022 | 2 |
| TDP-43 Pathology in Alzheimer's Disease. [PMID:34930382] | Meneses A, Koga S, O'Leary J, Dickson DW | Mol Neurodegener | 2021 | 2 |
| Protein transmission in neurodegenerative disease. [PMID:32203399] | Peng C, Trojanowski JQ, Lee VM | Nat Rev Neurol | 2020 | 2 |
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of [PMID:30335591] | Rusmini P, Cortese K, Crippa V, Cristofa | Autophagy | 2019 | 2 |
| N protein of PEDV plays chess game with host proteins by selective autophagy. [PMID:36861818] | Zhai X, Kong N, Zhang Y, Song Y, Qin W, | Autophagy | 2023 | 1 |
| PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. [PMID:36754049] | Hung ST, Linares GR, Chang WH, Eoh Y, Kr | Cell | 2023 | 1 |
| Selective Silencing of TDP-43 P. G376D Mutation Reverses Key Amyotrophic Lateral [PMID:41897327] | Romano R, Ruotolo G, Perrone F, Tomasell | Biomolecules | 2026 | 0 |
| Chemical and Molecular Strategies in Restoring Autophagic Flux in TDP-43 Protein [PMID:41900026] | Jamerlan A, Hulme J | Molecules (Basel, Switzerland) | 2026 | 0 |
| Axonal transport impairment as an upstream mechanism in amyotrophic lateral scle [PMID:41890591] | Gabbay U | Frontiers in neuroscience | 2026 | 0 |
| Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA- [PMID:41512823] | ["Guo L", "Mann J", "Mauna J", "Copley K | Molecular cell | 2026 | 0 |
| The Genetics of TDP-43 Type C Neurodegeneration: A Whole-Genome Sequencing Study [PMID:41883703] | Nassan M, Ayala I, Sloan J, Bonfitto A, | Neurology. Genetics | 2026 | 0 |
| Excitotoxicity in amyotrophic lateral sclerosis: a key pathogenic mechanism. [PMID:41890274] | Silva-Hucha S, Hernández RG, Baena-López | Brain communications | 2026 | 0 |
| Direct observation and quantification of single nanocondensates of the low compl [PMID:41654570] | ["Houx J", "Cussac J", "Copie T", "Gambi | Nature communications | 2026 | 0 |
| Small heat shock protein HSPB8 interacts with a pre-fibrillar TDP43 low complexi [PMID:41690263] | ["Jami K", "Corbett K", "Farb D", "Osumi | Biophysical chemistry | 2026 | 0 |
| Elucidation of Molecular Mechanisms of Lipid-Altered Cytotoxicity of TDP-43 Fibr [PMID:41609580] | ["Purvinsh Y", "Matveyenka M", "Kurouski | ACS chemical neuroscience | 2026 | 0 |
| Inertial Agitation in an NMR Magnet: Real-Time Monitoring of Protein Aggregation [PMID:41397930] | ["Lee J", "Jung S", "Yu S", "Park S", "K | Journal of the American Chemic | 2025 | 0 |
| Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. [PMID:38277467] | Seddighi S, Qi YA, Brown AL, Wilkins OG, | Science translational medicine | 2024 | 0 |
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 0 |
| C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy. [PMID:32878979] | Cook CN, Wu Y, Odeh HM, Gendron TF, Jans | Science translational medicine | 2020 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GLYCINE in their description or question text
No additional research found