protein

GBA1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GBA1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Glucocerebrosidase is a 59.7 kDa enzyme essential for glycolipid metabolism in the lysosome.

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🔬 Protein Info

Gene Symbol	GBA1PROTEIN
Protein Type	Hydrolase
Function	is a lysosomal hydrolase encoded by the GBA1 gene that catalyzes the hydrolysis of glucosylceramide to ceramide and glucose.
Subcellular Localization	</th><td>Lysosome</td></tr>
Amino Acids	536 aa
GeneCards	GBA1PROTEIN
Human Protein Atlas	GBA1PROTEIN
Signal peptide (1-19)	Directs protein to lysosome
Propeptide (20-39)	Cleaved during maturation
Catalytic domain (40-536)	Contains active site
Active site residues	Glu235 (nucleophile), Glu349 (acid/base)
N-glycosylation sites	Asn59, Asn146, Asn190
Saposin C binding site	Required for in vivo activity
Dimer interface	Forms functional homodimer
1OGS	Native GCase structure
Associated Diseases	Aging, Als, Alzheimer, Cancer, dementia with Lewy bodies
Known Drugs/Compounds	AAV5, AAV9, Ambroxol, Bi-Htfr1, BI-hTFR1, levodopa
Interactions	ABCA1, Actin, AKT, ALPHA-SYNUCLEIN, AMPK, AND
SciDEX Hypotheses	GBA1-Deficiency Disrupts Mitochondrial- Lysosomal PD-Associated GWAS Variants in CTSO and CTSF Genes Glucosylceramide Accumulation from GCase Deficienc (+1 more)
KG Connections	419 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GBA1 (Glucocerebrosidase) Protein

protein · 1352 words

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Pathway Diagram

graph TD
    GBA1PROTEIN["GBA1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GBA1PROTEIN -->|"implicated_in"| neurodegeneration
    style GBA1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning GBA1PROTEIN in their description or question text

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