protein

GAMMA-SECRETASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GAMMA-SECRETASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections

0Hypotheses

1Analyses

12Outgoing

14Incoming

0Experiments

1Debates

No summary available yet.

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🔬 Protein Info

Gene Symbol	GAMMA
Full Name	SECRETASE
Chromosome	14q24.2
Molecular Weight	230 kDa
Pathways	Notch
GeneCards	GAMMA
Human Protein Atlas	GAMMA
Genes	psen1 (chromosome 14q24.2) and psen2 (chromosome 1q42.13)
Size	~50 kDa; contains 9 transmembrane domains (TMDs)
Disease relevance	Over 300 mutations in psen1 and ~50 in psen2 cause familial Alzheimer's Disease, making psen1 the most commonly mutated gene in autosomal dominant AD.
Interactions	ALZHEIMER, APH1B, NCSTN, PEN2, PSEN1, PSEN2
KG Connections	17 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Gamma-Secretase Complex (γ-Secretase)

protein · 3346 words

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Pathway Diagram

graph TD
    GAMMA_SECRETASE["GAMMA-SECRETASE"]
    GAMMA_SECRETASE -->|"interacts"| HSPG2["HSPG2"]
    GAMMA_SECRETASE -->|"activates"| ALZHEIMER["ALZHEIMER"]
    GAMMA_SECRETASE -->|"activates"| Alzheimer_S_Disease["Alzheimer'S Disease"]
    GAMMA_SECRETASE -->|"activates"| disease["disease"]
    GAMMA_SECRETASE -->|"activates"| ALZHEIMER_S["ALZHEIMER'S"]
    GAMMA_SECRETASE -->|"inhibits"| NEURONS["NEURONS"]
    PSEN1["PSEN1"] -->|"involved_in"| GAMMA_SECRETASE
    APH1B["APH1B"] -->|"interacts"| GAMMA_SECRETASE
    PEN2["PEN2"] -->|"interacts"| GAMMA_SECRETASE
    NCSTN["NCSTN"] -->|"interacts"| GAMMA_SECRETASE
    PSEN2["PSEN2"] -->|"interacts"| GAMMA_SECRETASE
    GSK3B["GSK3B"] -->|"regulates"| GAMMA_SECRETASE
    LRP1["LRP1"] -->|"regulates"| GAMMA_SECRETASE

Outgoing (12)

Target	Relation	Type	Str
TREM2 proteolytic cleavage	regulates	process	0.90
nectin receptors	cleaves	protein	0.80
Nectin receptors	cleaves	protein	0.80
Nectin Receptors	cleaves	protein	0.80
TREM2 cleavage	regulates	process	0.70
sTREM2 generation	activates	process	0.70
ALZHEIMER'S	activates	concept	0.50
HSPG2	interacts_with	concept	0.50
NEURONS	inhibits	concept	0.50
ALZHEIMER	activates	gene	0.50
Alzheimer'S Disease	activates	disease	0.50
disease	activates	disease	0.50

Incoming (14)

Source	Relation	Type	Str
17996025	form the catalytic center of	paper	0.90
PSEN1	part_of	gene	0.80
PSEN1	involved_in	gene	0.60
APH1B	interacts_with	gene	0.50
PSEN1	interacts_with	gene	0.50
PEN2	interacts_with	gene	0.50
NCSTN	interacts_with	gene	0.50
PSEN2	interacts_with	gene	0.50
GSK3B	regulates	gene	0.50
LRP1	regulates	gene	0.50
PSEN1	regulates	gene	0.50
LRP8	regulates	gene	0.50
NCSTN	regulates	gene	0.50
PSEN2	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the optimal temporal windows for TREM2 inhibition vs activation in Alzh

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate proposed biphasic TREM2 modulation but couldn't define when to switch

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning GAMMA-SECRETASE in their description or question text

No additional research found