gene 1,004 words KG: GABRB3
Contents

GABRB3

🧬 Gene Info
Gene SymbolGABRB3
AliasesGABA-A receptor beta3 subunit
Chromosome15q12
Protein TypeReceptor
Functionis a critical component of many GABA-A receptor subtypes, including the predominant benzodiazepine-sensitive receptors in the thalamus and cortex.
Primary ExpressionBrain (thalamus, cortex, hippocampus), widespread CNS
Molecular Weight54 kDa
Amino Acids473 aa
UniProt IDP28472
OMIM137192
GeneCardsGABRB3
Human Protein AtlasGABRB3
Associated Diseasesneurodegeneration
InteractionsA2M, BCHE, CHRFAM7A, CNTN1, DNA, ESR1
KG Connections14 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (9)

TREM2-Dependent Microglial Senescence Transition
Score: 0.95
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69

Related Analyses (9)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (5)

Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40
Tau ASO Therapy
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (12 edges)

A2M interacts_with GABRB3
BCHE interacts_with GABRB3
CHRFAM7A interacts_with GABRB3
CNTN1 interacts_with GABRB3
ESR1 interacts_with GABRB3
GABRB3 interacts_with MAPT
GABRB3 interacts_with PSEN1
GABRB3 interacts_with SCARB2
GABRB3 interacts_with TFAM
GABRB3 interacts_with TREM2

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)