Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FZD4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | FZD4 |
| Full Name | Frizzled Class Receptor 4 |
| Chromosome | 11q14.2 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | endothelial cells, neural progenitors, and mature neurons |
| Pathways | pathway: - Binds Wnt1, Wnt3, Wnt3A, Wnt5A, Wnt, Wnt Signaling, Wnt signaling, pathway: - Binds Wnt ligands |
| UniProt ID | Q9ULV1 |
| NCBI Gene ID | 2762 |
| Ensembl ID | ENSG00000174804 |
| OMIM | 604579 |
| GeneCards | FZD4 |
| Human Protein Atlas | FZD4 |
| Associated Diseases | Familial Exudative Vitreoretinopathy, Alzheimer's Disease, Stroke |
| Interactions | PI3K, TGF, WNT |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["FZD4"]
N1["MICROGLIA"]
N0 -->|"activates"| N1
N2["PI3K"]
N0 -->|"activates"| N2
N3["TGF"]
N0 -->|"activates"| N3
N4["PI3K-AKT-mTOR signaling"]
N0 -->|"participates in"| N4
N5["TGF-beta signaling"]
N0 -->|"participates in"| N5
N6["WNT"]
N0 -->|"activates"| N6
N7["blood-brain barrier"]
N0 -->|"participates in"| N7
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classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
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class N0 gene
class N1 cell_type
class N2 gene
class N3 gene
class N4 pathway
class N5 pathway
class N6 gene
class N7 pathway| Target | Relation | Type | Str |
|---|---|---|---|
| MICROGLIA | activates | cell_type | 0.85 |
| TGF | activates | gene | 0.60 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.60 |
| TGF-beta signaling | participates_in | pathway | 0.60 |
| PI3K | activates | gene | 0.60 |
| WNT | activates | gene | 0.60 |
| blood-brain barrier | participates_in | pathway | 0.60 |
| WNT | associated_with | gene | 0.60 |
| microglia | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning FZD4 in their description or question text
No additional research found