protein

ERLIN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERLIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

9Outgoing

1Incoming

0Experiments

0Debates

Summary

ERLIN1 is a protein involved in neurodegeneration research. Key relationships include: associated with, interacts with, implicated in. Associated with Ms. Connected to 11 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ERLIN1
Aliases	Erlin-1
Protein Type	Gene
Function	is an SPFH-domain protein enriched in cholesterol-rich ER subdomains.
Molecular Weight	400 kDa
Amino Acids	299 aa
Pathways	Signaling:** Modulates various signaling pathways
GeneCards	ERLIN1
Human Protein Atlas	ERLIN1
Associated Diseases	Demyelination, Ms, Neurodegeneration
Interactions	BECN1
KG Connections	10 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ERLIN1 Gene

gene · 861 words

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ERLIN1 Protein (Erlin-1)

protein · 739 words

→

Pathway Diagram

graph TD
    ERLIN1["ERLIN1"]
    TREM2["TREM2"]
    ERLIN1 -->|"associated with"| TREM2
    OxPC["OxPC"]
    ERLIN1 -->|"associated with"| OxPC
    Neurodegeneration["Neurodegeneration"]
    ERLIN1 -->|"associated with"| Neurodegeneration
    Demyelination["Demyelination"]
    ERLIN1 -->|"associated with"| Demyelination
    Microglia["Microglia"]
    ERLIN1 -->|"associated with"| Microglia
    Ms{"Ms"}
    ERLIN1 -->|"associated with"| Ms
    AUTOPHAGY["AUTOPHAGY"]
    ERLIN1 -->|"associated with"| AUTOPHAGY
    BECN1["BECN1"]
    ERLIN1 -->|"interacts with"| BECN1
    Autophagy(["Autophagy"])
    ERLIN1 -->|"associated with"| Autophagy
    neurodegeneration["neurodegeneration"]
    ERLIN1 -->|"implicated in"| neurodegeneration
    AMBRA1["AMBRA1"]
    AMBRA1 -->|"associated with"| ERLIN1
    style ERLIN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

Target	Relation	Type	Str
TREM2	associated_with	gene	0.80
OxPC	associated_with	chemical	0.80
Demyelination	associated_with	phenotype	0.80
Neurodegeneration	associated_with	phenotype	0.80
Microglia	associated_with	cell_type	0.80
Ms	associated_with	disease	0.65
AUTOPHAGY	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
BECN1	interacts_with	gene	0.60

Incoming (1)

Source	Relation	Type	Str
AMBRA1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ERLIN1 in their description or question text

No additional research found