gene 861 words KG: ERLIN1
Contents

ERLIN1 Gene

🧬 Gene Info
Gene SymbolERLIN1
AliasesErlin-1
Protein TypeGene
Functionis an SPFH-domain protein enriched in cholesterol-rich ER subdomains.
Molecular Weight400 kDa
Amino Acids299 aa
PathwaysSignaling:** Modulates various signaling pathways
GeneCardsERLIN1
Human Protein AtlasERLIN1
Associated DiseasesDemyelination, Ms, Neurodegeneration
InteractionsBECN1
KG Connections10 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.95
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.62

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (7)

Neurodegeneration
disease · KG edge: implicated_in
Microglia in Neurodegeneration
entity · KG edge: associated_with
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
AMBRA1 Gene
gene · KG edge: associated_with

Knowledge Graph (10 edges)

AMBRA1 associated_with ERLIN1
ERLIN1 interacts_with BECN1
ERLIN1 associated_with TREM2
ERLIN1 associated_with OxPC
ERLIN1 associated_with Demyelination
ERLIN1 associated_with AUTOPHAGY
ERLIN1 associated_with Ms
ERLIN1 associated_with Autophagy
ERLIN1 associated_with Neurodegeneration
ERLIN1 associated_with Microglia

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