gene 694 words KG: ERCC1
Contents

ERCC1 — Excision Repair Cross-Complementation Group 1

🧬 Gene Info
Gene SymbolERCC1
Full NameExcision Repair Cross-Complementation Group 1
FunctionERCC1 functions as part of a heterodimer with XPF (ERCC4) to perform the critical incision step in nucleotide excision repair:
Primary Expressionall brain regions
PathwaysApoptosis
Ensembl IDENSG00000112020
GeneCardsERCC1
Human Protein AtlasERCC1
Associated DiseasesMs, Osteoporosis
InteractionsAGING, AND, APOPTOSIS, EFNB1, EXERCISE, P21
KG Connections39 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (5)

Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro
Score: 0.64
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.47
Cross-Seeding Prevention Strategy
Score: 0.69
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
Lysosomal Membrane Repair Enhancement
Score: 0.54

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (6)

Cardiac MIBG Scan for Parkinsonism
diagnostic · KG edge: therapeutic_target
Apoptosis in Neurodegeneration
entity · KG edge: activates
Exercise-BDNF-Mitophagy Biomarker Study in PD
experiment · KG edge: activates
efnb1
gene · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates

Knowledge Graph (12 edges)

EFNB1 therapeutic_target ERCC1
ERCC1 therapeutic_target EFNB1
ERCC1 activates EFNB1
EFNB1 activates ERCC1
PI3K therapeutic_target ERCC1
ERCC1 therapeutic_target PI3K
ERCC1 therapeutic_target Longevity
ERCC1 therapeutic_target Aging
ERCC1 associated_with Ms
ERCC1 therapeutic_target Cardiac

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)