concept

CONNEXIN43

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CONNEXIN43: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

1Analyses

34Outgoing

5Incoming

0Experiments

1Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	CONNEXIN43
Key Genes/Proteins	GJA1
Related Diseases	Alzheimer's disease, Ischemic Brain Injury

Pathway Diagram

graph TD
    CONNEXIN43["CONNEXIN43"]
    CONNEXIN43 -->|"expressed in"| Astrocytes["Astrocytes"]
    CONNEXIN43 -->|"interacts"| Hemichannel["Hemichannel"]
    CONNEXIN43 -->|"mediates"| Gap_Junctions["Gap Junctions"]
    CONNEXIN43 -->|"mediates"| Ion_Homeostasis["Ion Homeostasis"]
    CONNEXIN43 -->|"contributes to"| Ischemic_Brain_Injury["Ischemic Brain Injury"]
    CONNEXIN43 -->|"interacts"| P2_RECEPTORS["P2 RECEPTORS"]
    GJA1["GJA1"] -->|"encodes"| CONNEXIN43
    Gap26["Gap26"] -->|"inhibits"| CONNEXIN43
    P2_Receptors["P2 Receptors"] -->|"interacts"| CONNEXIN43

Outgoing (34)

Target	Relation	Type	Str
Astrocytes	expressed_in	cell_type	0.95
Hemichannel	involved_in	process	0.95
Alzheimer's disease	associated_with	disease	0.95
Hemichannel	interacts_with	protein	0.95
Alzheimer's Disease	associated_with	disease	0.95
Astrocytes	expressed_in	cell_type	0.95
Gap Junctions	mediates	process	0.90
P2 RECEPTORS	interacts_with	receptor	0.90
Ion Homeostasis	mediates	process	0.90
Ischemic Brain Injury	associated_with	disease	0.90
Apoptotic Cell Death	causes	process	0.85
Microglia	expressed_in	cell_type	0.85
Hemichannels	mediates	process	0.85
Metabolic Support	mediates	process	0.85
Hemichannels	involved_in	protein	0.85
Glial Network Signalling	mediates	process	0.85
Apoptosis	causes	process	0.80
MICROGLIA	inhibits	cell_type	0.80
ASTROCYTIC	expressed_in	cell_type	0.80
functional_recovery	inhibition_improves	process	0.80
Amyloidosis	contributes_to	disease	0.80
MICROGLIA	regulates	cell_type	0.80
cognitive deficits	prevents	process	0.80
cognitive deficits	mitigates	process	0.80
ALZHEIMER	therapeutic_target	disease	0.80
functional recovery	inhibits	process	0.80
functional recovery	improves	process	0.80
gap_junction_pathway	forms	pathway	0.80
microglia reactivity	regulates	process	0.60
Alzheimer's disease	therapeutic_target	disease	0.60
Calcium signaling	regulates	pathway	0.60
Gap junctions	involved_in	pathway	0.60
CRF-R1	interacts_with	protein	0.60
Neuroinflammation	contributes_to	pathway	0.60

Incoming (5)

Source	Relation	Type	Str
GJA1	encodes	gene	0.95
Gap26	inhibits	compound	0.85
P2 Receptors	interacts_with	receptor	0.80
GJA1	encodes	gene	0.80
GJA1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Mitochondrial transfer between astrocytes and neurons

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.813

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Mitochondrial transfer between astrocytes and neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning CONNEXIN43 in their description or question text

No additional research found