Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ASTROCYTIC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| models-3xtg-ad-mouse | describes | wiki | 0.90 |
| hypotheses-gap-junction-dysfunction-parkinsons | describes | wiki | 0.90 |
| CONNEXIN43 | expressed_in | protein | 0.80 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Cx43 knockdown effects on mitochondrial transfer | exploratory | osteoarthritis | 0.900 | 0.00 | human bone marrow-derived MSCs | proposed | N/A |
| Confocal imaging of MSC-chondrocyte interactions during mitochondrial | exploratory | osteoarthritis | 0.850 | 0.00 | human bone marrow-derived MSCs | proposed | N/A |
| s:** - ALOX15 overexpression in healthy astrocytes should be protectiv | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $200,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134] | Yang J, Borchert A, Kuhn H | J Biol Chem | 2026 | 1 |
| miR-375 protects against acetaminophen-induced acute liver failure by orchestrat [PMID:40598772] | Wang Y, Liu J, Zhu S, Hu S, Chen X, Mand | Mol Ther | 2025 | 1 |
| Defective thyroid hormone transport to the brain leads to astroglial alterations [PMID:39097035] | Guillén-Yunta M, García-Aldea Á, Valcárc | Neurobiol Dis | 2024 | 1 |
| Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting C [PMID:36987924] | Cai W, Liu L, Shi X, Liu Y, Wang J, Fang | Circulation | 2023 | 1 |
| Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated [PMID:36323829] | Tong J, Lan XT, Zhang Z, Liu Y, Sun DY, | Acta Pharmacol Sin | 2023 | 1 |
| NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. [PMID:37683629] | Zhan R, Meng X, Tian D, Xu J, Cui H, Yan | Neuron | 2023 | 1 |
| Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration. [PMID:34199470] | Boal AM, Risner ML, Cooper ML, Wareham L | Cells | 2021 | 1 |
| CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistan [PMID:32106859] | Zhang H, Deng T, Liu R, Ning T, Yang H, | Mol Cancer | 2020 | 1 |
| Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b [PMID:24293102] | Zhao Y, Bhattacharjee S, Jones BM, Hill | Mol Neurobiol | 2014 | 1 |
| The SLC16 gene family - structure, role and regulation in health and disease. [PMID:23506875] | Halestrap AP | Mol Aspects Med | 2013 | 1 |
| Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline [PMID:41618855] | ["Ying H", "Fan H", "Wang Y", "Jiang R", | Advanced science (Weinheim, Ba | 2026 | 0 |
| ALOX15 exerts tumor-suppressive role in head and neck squamous cell carcinoma vi [PMID:41820595] | Liu A, Zhang X, Li R, Zhang Y, Yang Z, Z | Functional & integrative genom | 2026 | 0 |
| Prenatal lipopolysaccharide exposure programs cardiac fibrosis via dysregulating [PMID:41789580] | Wen Y, Yuan Y, Zhang H, Liu Y | Molecular medicine reports | 2026 | 0 |
| Astrocytes Protect Brain Metastatic Breast Cancer Cells From Chemotherapy Throug [PMID:41486609] | Yakati V, Rao SS | Biotechnol Bioeng | 2026 | 0 |
| Inhibition of Calcium-Dependent Lipid Droplets Relocation of ACSL4-PKCβ-ALOX15 C [PMID:41589658] | Hou G, Luan J, Xu X, Qin J, Ma S et al. | Adv Sci (Weinh) | 2026 | 0 |
| Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892] | Lin D, Li K, Kuang W, Chen Z, Zhang M | World J Mens Health | 2026 | 0 |
| Sanhua essential oil exerts antidepressant effects in breast cancer-related depr [PMID:41722126] | Li X, Xu Z, Ju P, Dong M, Wang Y et al. | Phytomedicine | 2026 | 0 |
| The AP-1 transcription factors differentially regulate Cx43 expression in a ERK1 [PMID:41930557] | Basque A, Izichkis LS, Mellet C, Martin | Reprod Biol | 2026 | 0 |
| Oxidative Stress Mediated by Macrophages Promotes Angiogenesis and Early Develop [PMID:41750540] | Man GCW, Borchert A, Zhang T, Hung SW, K | Antioxidants (Basel, Switzerla | 2026 | 0 |
| Danggui Sini decoction attenuates intervertebral disc degeneration by regulating [PMID:41812505] | Chen S, Zhou X, Wang W, Zheng Y, Kang R, | International immunopharmacolo | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ASTROCYTIC in their description or question text
Score: 0.551 · neuroinflammation · 2026-04-20
## Mechanistic Overview Astrocytic SPP1 Modulation Through STAT3-Dependent Transcriptional Control starts from the claim
Score: 0.529 · neurodegeneration · 2026-04-02
## Mechanistic Overview Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioenergetics starts from the claim that mo
Score: 0.499 · synaptic biology · 2026-04-26
The secretion of soluble complement regulators CD55 and CD46 by reactive astrocytes represents a non-cell-autonomous mec
Score: 0.459 · neuroinflammation · 2026-04-21
## Mechanistic Overview Astrocytic SPP1 Modulation via STAT3-Dependent Transcriptional Control starts from the claim tha
Score: 0.450 · neurodegeneration · 2026-04-21
## Mechanistic Overview Astrocytic APOE4 Disruption of GABAergic Support Increasing Neuronal Vulnerability starts from t
Score: 0.447 · neuroinflammation · 2026-04-21
## Mechanistic Overview Astrocytic SPP1 Modulation for Neuroinflammatory Resolution starts from the claim that modulatin
Score: 0.387 · immunomics · 2026-04-26
Elevated circulating high-sensitivity C-reactive protein (hs-CRP) functions as a disease-modifying factor through comple
Score: 0.380 · immunomics · 2026-04-27
This hypothesis proposes that selective upregulation of CXCL12 in astrocytes can restore CNS immune privilege by disrupt
Score: 0.380 · connectomics · 2026-04-27
This hypothesis proposes that astrocytic TREM2-like receptors (TREML2) regulate synaptic plasticity through a fundamenta
Score: 0.380 · metabolomics · 2026-04-27
This hypothesis proposes that enhancing ketone body synthesis specifically within astrocytes through overexpression of 3
Score: 0.380 · developmental neurobiology · 2026-04-27
The astrocytic metabolic trained immunity hypothesis proposes that perinatal immune activation fundamentally reprograms
Score: 0.380 · metabolomics · 2026-04-26
This hypothesis proposes that enhancing endogenous ketone body synthesis within astrocytes through targeted overexpressi
Score: 0.380 · synaptic biology · 2026-04-27
**Molecular Mechanism and Rationale** Astrocytic release of soluble complement regulators CD55 and CD46, rather than me
Score: 0.380 · immunomics · 2026-04-27
Elevated circulating high-sensitivity C-reactive protein (hs-CRP) serves as a disease-modifying target through direct ac
Score: 0.380 · neuroscience · 2026-04-27
This hypothesis proposes that TREM2 signaling in microglia directly regulates astrocytic calcium dynamics to control gly