Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Hemichannel: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| degenerative stress spread | promotes | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Connexin43 | interacts_with | protein | 0.95 |
| Connexin43 | involved_in | protein | 0.95 |
| GJA1 | expressed_in | gene | 0.95 |
| GJA1 | associated_with | protein | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CX43 hemichannel engineering enables size-selective mitochon | 0.686 | neurodegeneration | Mitochondrial transfer between astrocyte |
| Gamma entrainment restores astrocyte-neuron metabolic coupli | 0.675 | Alzheimer's disease | Gamma entrainment therapy to restore hip |
| TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between S | 0.663 | cell biology | What is the relative contribution of con |
| Blocking Astrocyte-Mediated Tau Re-Spreading via Cx43 Hemich | 0.570 | neuroscience | Trans-synaptic tau spreading and propaga |
| Closed-loop neuromodulation-inspired cytokine axis suppressi | 0.530 | cell biology | - |
| Gap Junction Hemichannel Modulation for Controlled Mitochond | 0.361 | neurodegeneration | Mitochondrial transfer between neurons a |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Cx43 knockdown effects on mitochondrial transfer | exploratory | osteoarthritis | 0.900 | 0.00 | human bone marrow-derived MSCs | proposed | N/A |
| Network pharmacology analysis of QTJD active compounds and pathways | exploratory | Mycoplasma pneumoniae pneumoni | 0.900 | 0.00 | computational network analysis | proposed | N/A |
| Leukocyte gene expression analysis in COVID-19 patients | exploratory | COVID-19 | 0.900 | 0.00 | human leukocytes from COVID-19 | proposed | N/A |
| Confocal imaging of MSC-chondrocyte interactions during mitochondrial | exploratory | osteoarthritis | 0.850 | 0.00 | human bone marrow-derived MSCs | proposed | N/A |
| Proposed experiment from debate on Mitochondrial transfer between astr | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Proposed experiment from debate on Mitochondrial transfer between astr | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| AAV-LRRK2 IND-Enabling Study Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Gap Junction Dysfunction Validation in Parkinson's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| AAV-LRRK2 Gene Therapy IND-Enabling Study Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Experiment Design: Metal Ion-Synuclein-Mitochondria Axis in Parkinson' | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Astrocytic Connexin43 in Alzheimer's disease: mechanisms, interaction with P2 re [PMID:41062060] | Xiong W, Su Y, Verkhratsky A, Yi C | Neuropharmacology | 2026 | 1 |
| Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates co [PMID:40595567] | Su Y, Li H, Zhang W, Tao S, Wang Q, Zhan | Nat Commun | 2025 | 1 |
| Should it stay or should it go: gap junction protein GJA1/Cx43 conveys damaged l [PMID:39394955] | Domingues N, Ribeiro-Rodrigues T, Girão | Autophagy | 2024 | 1 |
| Connexin 43 regulates intercellular mitochondrial transfer from human mesenchyma [PMID:39390589] | Irwin RM, Thomas MA, Fahey MJ, Mayán MD, | Stem Cell Res Ther | 2024 | 1 |
| Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration. [PMID:34199470] | Boal AM, Risner ML, Cooper ML, Wareham L | Cells | 2021 | 1 |
| Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline [PMID:41618855] | ["Ying H", "Fan H", "Wang Y", "Jiang R", | Advanced science (Weinheim, Ba | 2026 | 0 |
| Prenatal lipopolysaccharide exposure programs cardiac fibrosis via dysregulating [PMID:41789580] | Wen Y, Yuan Y, Zhang H, Liu Y | Molecular medicine reports | 2026 | 0 |
| Astrocytes Protect Brain Metastatic Breast Cancer Cells From Chemotherapy Throug [PMID:41486609] | Yakati V, Rao SS | Biotechnol Bioeng | 2026 | 0 |
| Metabolites released from apoptotic cells in central nervous system orchestrates [PMID:41518198] | Xiao F, Tan X, He A, Zhou Y, Xu K et al. | Autophagy | 2026 | 0 |
| The AP-1 transcription factors differentially regulate Cx43 expression in a ERK1 [PMID:41930557] | Basque A, Izichkis LS, Mellet C, Martin | Reprod Biol | 2026 | 0 |
| Inhibition of NETs prevents doxorubicin-induced cardiotoxicity by attenuating IL [PMID:39805175] | Li K, Jiang KM, Wang Y, Hu F, Zhu XC, Su | International immunopharmacolo | 2025 | 0 |
| Glial cell line-derived neurotrophic factor improves impaired colonic motility i [PMID:40062335] | ["Yang W", "Liu R", "Xu F"] | World journal of gastroenterol | 2025 | 0 |
| Connexin and Pannexin Hemichannels: Broad-Spectrum Players in Neuroinflammatory [PMID:40956013] | ["S\u00e1ez J", "Ocaranza F", "Prieto-Vi | Journal of neurochemistry | 2025 | 0 |
| Astroglial toxicity promotes synaptic degeneration in the thalamocortical circui [PMID:36602862] | Marsan E, Velmeshev D, Ramsey A, Patel R | The Journal of clinical invest | 2023 | 0 |
| Overlap in synaptic neurological condition susceptibility pathways and the neura [PMID:37807670] | ["Frederiksen S", "Wicki-Stordeur L", "S | Channels (Austin, Tex.) | 2023 | 0 |
| Harlequin syndrome associated with thoracic epidural anaesthesia. [PMID:35118419] | Persson RM, Tellnes K, Hoven H, Haaverst | Anaesthesia reports | 2022 | 0 |
| Transmission dynamics of a linear vanA-plasmid during a nosocomial multiclonal o [PMID:34285270] | Fujiya Y, Harada T, Sugawara Y, Akeda Y, | Scientific reports | 2021 | 0 |
| The role of vimentin, Connexin-43 proteins, and oxidative stress in the protecti [PMID:33098837] | ["Abdel-Wahab B", "Salem S", "Mohammed H | European journal of pharmacolo | 2021 | 0 |
| High resolution spatiotemporal patterns of seawater temperatures across the Beli [PMID:33199700] | Helmuth B, Leichter JJ, Rotjan RD, Casti | Scientific data | 2020 | 0 |
| Levo-corydalmine Attenuates Vincristine-Induced Neuropathic Pain in Mice by Upre [PMID:31617070] | Zhou L, Ao L, Yan Y, Li C, Li W, Ye A, L | Neurotherapeutics : the journa | 2020 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Hemichannel in their description or question text