protein

CYCSPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CYCSPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	CYCSPROTEIN
Function	is a mobile electron shuttle in the mitochondrial intermembrane space
Subcellular Localization	</span><span class="infobox-value">Mitochondrial intermembrane space</span></div>
Amino Acids	104 aa
GeneCards	CYCSPROTEIN
Human Protein Atlas	CYCSPROTEIN
Heme attachment	The iron-porphyrin ring is covalently linked via thioether bonds to Cys14 and Cys17 through a conserved CXXCH motif. His18 and Met80 serve as axial ligands to the central iron atom.
Redox-active iron	Cycles between Fe²⁺ (reduced, ferrocytochrome c) and Fe³⁺ (oxidized, ferricytochrome c) during electron transfer, with a midpoint potential of +260 mV.
Structural compactness	The protein lacks significant disordered regions, contributing to its extreme stability (Tm > 80 °C) and evolutionary conservation (>95 % identity between human and horse sequences).
Associated Diseases	Als, Alzheimer, Dementia, Diabetes, Inflammation, Ms
Known Drugs/Compounds	rapamycin
Interactions	aco2, ACO2, ACTB, APP, ATG5, ATP
KG Connections	355 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Cytochrome c Protein

protein · 1276 words

→

Pathway Diagram

graph TD
    CYCSPROTEIN["CYCSPROTEIN"]
    neurodegeneration["neurodegeneration"]
    CYCSPROTEIN -->|"implicated_in"| neurodegeneration
    style CYCSPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CYCSPROTEIN in their description or question text

No additional research found