Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about COX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| ALZHEIMER'S DISEASE | associated_with | disease | 0.90 |
| PARKINSON'S DISEASE | associated_with | disease | 0.90 |
| Eicosanoids | catalyzes | compound | 0.90 |
| Alzheimer's disease | implicated_in | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CYTOKINES/CHEMOKINES | activates | protein | 0.90 |
| CYTOKINES | activates | protein | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Near-infrared light therapy stimulates COX4-dependent mitoch | 0.742 | neurodegeneration | Mitochondrial transfer between astrocyte |
| TLR2 Recognition of Gut-Derived Fungal and Bacterial D-Alany | 0.550 | neurodegeneration | How does gut microbiome dysbiosis contri |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| s:** - Test MCU overexpression specifically in layer II neurons in hea | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $200,000 |
| Proposed experiment from debate on Mitochondrial transfer between astr | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Mechanism: Selective Vulnerability of Dopaminergic Neurons in Parkinso | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Ferroptosis Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| GLP-1 Agonist Neuroprotection Mechanism in PD | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Cytochrome Therapeutics | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Peroxisomal Dysfunction Validation in Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Prodromal Parkinson's Disease Biomarker Development — Early Detection | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Synaptic Mitochondrial Resilience Enhancement for Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| Wilson Disease Neurodegeneration: Mechanism and Therapeutic Response | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $7,500,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Increased mitophagy protects cochlear hair cells from aminoglycoside-induced dam [PMID:35471096] | Zhang Y, Fang Q, Wang H, Qi J, Sun S, Li | Autophagy | 2023 | 1 |
| BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains. [PMID:32722981] | Wu X, Zheng Y, Liu M, Li Y, Ma S, Tang W | Autophagy | 2021 | 1 |
| SIRT5 regulation of ammonia-induced autophagy and mitophagy. [PMID:25700560] | Polletta L, Vernucci E, Carnevale I, Arc | Autophagy | 2015 | 1 |
| PRKAB2 as a tumor suppressor in renal cell carcinoma: inhibiting mitophagy via t [PMID:41612594] | Chen K, Zhang Y, Ruan H, Wei Z, Wang K, | Autophagy | 2026 | 0 |
| ROS-responsive nanogels for brain targeted delivery of icariin in the treatment [PMID:41197818] | ["Li X", "Huang J", "Zhou Y", "Chen X", | International journal of pharm | 2026 | 0 |
| Single-Cell RNA Sequencing and Network Pharmacology Reveal the Potential Role of [PMID:41610872] | ["Niu J", "Wang L", "Qi J", "Lu G"] | The journal of gene medicine | 2026 | 0 |
| Integrated Profiling of DEHP-Induced Hippocampal Neurotoxicity in Adult Female R [PMID:41600627] | Bai J, Li J, Tang L, Sun W, Gao F, Zhang | Toxics | 2026 | 0 |
| Functional and Molecular Characterization of Melamine-Induced Disruption of Huma [PMID:41596180] | ["Luongo F", "Annunzi E", "Ponchia R", " | Antioxidants (Basel, Switzerla | 2026 | 0 |
| Exploring the lactate-metabolism related characteristics during the development [PMID:41815173] | Wang C, Zhang R, Li S, Kang Z, Xia S, Li | Translational cancer research | 2026 | 0 |
| Developmental toxicity of carboxylated microplastics in zebrafish mediated by mi [PMID:41265820] | ["Li Y", "Ni Y", "Dong C", "Zhang J", "G | Environmental pollution (Barki | 2026 | 0 |
| Complex IV deficiency due to COX4I1 deep intronic and de novo variants results i [PMID:41203052] | Ugarteburu O, Farré-Tarrats L, Muñoz-Puj | Mitochondrion | 2026 | 0 |
| Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078] | ["Ranjitha V", "Kumar A", "Kaalappa P"] | Pharmaceutical research | 2025 | 0 |
| 810-nm Photobiomodulation Evokes Glutamate Release in Normal and Rotenone-Dysfun [PMID:39851493] | ["Ravera S", "Farsetti E", "Maura G", "M | Cells | 2025 | 0 |
| Mongolian medicine Wulanwendusu-11 alleviates myocardial ischemia-reperfusion in [PMID:41586357] | ["Wuyunsiqin", "Bai T", "Yang D", "Hashe | Frontiers in microbiology | 2025 | 0 |
| Near-Infrared Photoimmunotherapy in Brain Tumors-An Unexplored Frontier. [PMID:40430568] | ["Yamaguchi H", "Okada M", "Otani T", "O | Pharmaceuticals (Basel, Switze | 2025 | 0 |
| Evaluation of local and systemic photobiomodulation in only single-implant inser [PMID:40531278] | ["Pucca D", "Pinheiro S"] | Oral and maxillofacial surgery | 2025 | 0 |
| Comparison of the efficacy of 12 interventions in the treatment of diabetic foot [PMID:40821981] | ["Hu X", "Meng H", "Liang J", "An H", "Z | PeerJ | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| Dose-dependent effects of transcranial photobiomodulation on brain temperature i [PMID:39370461] | ["Weerasekera A", "Coelho D", "Ratai E", | Lasers in medical science | 2024 | 0 |
| Mystery of gamma wave stimulation in brain disorders. [PMID:39695746] | ["Deng Q", "Wu C", "Parker E", "Zhu J", | Molecular neurodegeneration | 2024 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning COX in their description or question text
No additional research found