| Gene Symbol | CLCN8 |
| Full Name | Chloride Voltage-Gated Channel 8 |
| Chromosome | 8q24.22 |
| Protein Type | Gene |
| Function | is a human gene encoding a voltage-gated chloride channel protein belonging to the CLCN family of chloride channels and transporters[@jentsch2000]. |
| Primary Expression | the central nervous system where it plays critical roles in neuronal chloride homeostasis and synaptic inhibition[@staley2006] |
| Molecular Weight | 88 kDa |
| Amino Acids | 803 aa |
| Exons | 26 |
| GeneCards | CLCN8 |
| Human Protein Atlas | CLCN8 |
| Proton glutamate (E166) | Critical for proton coupling and chloride transport |
| Gating glutamate (E207) | Involved in voltage-dependent gating |
| Dimerization domain | Forms the structural basis for dimer assembly |
| NBF1 and NBF2 | Nucleotide binding folds that may regulate channel activity |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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