gene

CERS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CERS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

0Hypotheses

0Analyses

7Outgoing

2Incoming

0Experiments

0Debates

Summary

Comprehensive coverage of CERS1 in ceramide biosynthesis, sphingolipid metabolism, and neurodegenerative diseases including Parkinson's disease, ALS, and neuronal ceroid lipofuscinosis

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CERS1
Full Name	Ceramide Synthase 1
Chromosome	19p13.3
Protein Type	Enzyme
Function	is a critical enzyme in the biosynthesis of ceramides, a fundamental class of sphingolipids essential for cellular membrane structure and signaling functions.
Molecular Weight	48 kDa
Amino Acids	422 aa
Pathways	Mitophagy
UniProt ID	Q8IV08
NCBI Gene ID	24145
Ensembl ID	ENSG00000154188
OMIM	606919
GeneCards	CERS1
Human Protein Atlas	CERS1
Associated Diseases	neurodegeneration
Interactions	PINK1
KG Connections	9 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CERS1 — AlphaFold Q8IV08 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CERS1 — Ceramide Synthase 1

gene · 1882 words

→

CERS1 Protein

protein · 657 words

→

Pathway Diagram

graph TD
    CERS1["CERS1"]
    Als{"Als"}
    CERS1 -->|"activates"| Als
    Tumor{"Tumor"}
    CERS1 -->|"regulates"| Tumor
    Carcinoma{"Carcinoma"}
    CERS1 -->|"activates"| Carcinoma
    Cancer{"Cancer"}
    CERS1 -->|"activates"| Cancer
    DRP1["DRP1"]
    CERS1 -->|"regulates"| DRP1
    Mitophagy(["Mitophagy"])
    CERS1 -->|"regulates"| Mitophagy
    neurodegeneration["neurodegeneration"]
    CERS1 -->|"implicated in"| neurodegeneration
    PINK1["PINK1"]
    PINK1 -->|"activates"| CERS1
    PARKIN["PARKIN"]
    PARKIN -->|"regulates"| CERS1
    style CERS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (7)

Target	Relation	Type	Str
Als	activates	disease	0.65
Tumor	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
DRP1	regulates	gene	0.60
Mitophagy	regulates	pathway	0.60
sphingolipid metabolism	participates_in	pathway	0.55

Incoming (2)

Source	Relation	Type	Str
PINK1	activates	gene	0.60
PARKIN	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CERS1 in their description or question text

No additional research found