gene

CASS2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

6Outgoing

8Incoming

0Experiments

0Debates

Summary

CASS2 (CRADD) is a death domain-containing adaptor protein that mediates caspase-2 activation and PIDDosome formation. It plays critical roles in apoptosis, necroptosis, and is implicated in Alzheimer's disease, Parkinson's disease, and ALS pathogenesis.

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🧬 Gene Info

Gene Symbol	CASS2
Full Name	CASP2 and RIPK1 Domain Containing Adaptor
Aliases	CRADD
Chromosome	10p15.1
Function	encodes a protein of 312 amino acids with a molecular weight of approximately 35 kDa.
Molecular Weight	35 kDa
Amino Acids	312 aa
Ensembl ID	ENSG00000103811
GeneCards	CASS2
Human Protein Atlas	CASS2
Associated Diseases	Alzheimer, Autoimmune, Cancer
Interactions	CASS4
KG Connections	14 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CASS2 — CASP2 and RIPK1 Domain Containing Adaptor

gene · 1955 words

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Pathway Diagram

graph TD
    CASS2["CASS2"]
    Alzheimer{"Alzheimer"}
    CASS2 -->|"associated_with"| Alzheimer
    Cancer{"Cancer"}
    CASS2 -->|"associated_with"| Cancer
    Autoimmune{"Autoimmune"}
    CASS2 -->|"associated_with"| Autoimmune
    Cell_Cycle(["Cell Cycle"])
    CASS2 -->|"associated_with"| Cell_Cycle
    AURKA["AURKA"]
    AURKA -->|"associated_with"| CASS2
    SRC["SRC"]
    SRC -->|"associated_with"| CASS2
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated_with"| CASS2
    CASS4["CASS4"]
    CASS4 -->|"associated_with"| CASS2
    AND["AND"]
    AND -->|"associated_with"| CASS2
    FYN["FYN"]
    FYN -->|"associated_with"| CASS2
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated_with"| CASS2
    CANCER["CANCER"]
    CANCER -->|"associated_with"| CASS2
    CASS2 -->|"interacts_with"| CASS4
    neurodegeneration["neurodegeneration"]
    CASS2 -->|"implicated_in"| neurodegeneration

Outgoing (6)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Autoimmune	associated_with	disease	0.65
Cell Cycle	associated_with	pathway	0.60
CASS4	interacts_with	gene	0.50
SRC	co_expressed_with	gene	0.50

Incoming (8)

Source	Relation	Type	Str
ALZHEIMER	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
AURKA	associated_with	gene	0.60
SRC	associated_with	gene	0.60
CASS4	associated_with	gene	0.60
FYN	associated_with	gene	0.60
AURKA	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CASS2 in their description or question text

No additional research found